Red aggregation-induced emission luminogen and Gd3+ codoped mesoporous silica nanoparticles as dual-mode probes for fluorescent and magnetic resonance imaging
Red aggregation-induced emission luminogen and Gd3+ codoped mesoporous silica nanoparticles as dual-mode probes for fluorescent and magnetic resonance imaging
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红色聚集诱导发射发光体和 Gd3 共掺杂介孔二氧化硅纳米颗粒作为荧光和磁共振成像双模式探针
DOI：
10.1016/j.jcis.2020.02.009
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发表时间：
2020
影响因子：
9.9
通讯作者：
Wei Yen
中科院分区：
文献类型：
--
作者：
He Ziyang;Jiang Ruming;Long Wei;Huang Hongye;Liu Meiying;Feng Yulin;Zhou Naigen;Ouyang Hui;Zhang Xiaoyong;Wei Yen
荧光成像和磁共振成像已成为辅助治疗和诊断的研究热点。然而，传统的荧光探针或造影剂具有难以克服的弱点。在这项工作中，我们报告了制备的双模式探针的基础上，介孔二氧化硅纳米材料（MSNs），这是掺杂与聚集诱导发射（AIE）染料和Gd 3+通过直接溶胶-凝胶法。在该体系中，所制备的材料发出强烈的红色荧光，最大发射波长位于669 nm，可作为荧光显微成像的有效荧光探针。此外，Gd 3+的引入使得纳米颗粒在应用于对比增强磁共振（MR）成像时成为有效的造影剂，因为它们可以提高MR成像的对比度。这些纳米颗粒的优异的生物相容性，通过一个典型的CCK-8测定，以及它们在荧光细胞成像和MR成像的性能表明其在生物医学成像中的应用潜力。
Fluorescence imaging and magnetic resonance imaging have been research hotspots for adjuvant therapy and diagnosis. However, traditional fluorescent probes or contrast agents possess insurmountable weaknesses. In this work, we reported the preparation of dual-mode probes based on mesoporous silica nanomaterials (MSNs), which were doped with an aggregation-induced emission (AIE) dye and Gd3+through a direct sol-gel method. In this system, the obtained materials emitted strong red fluorescence, in which the maximum emission wavelength was located at 669 nm, and could be applied as effective fluorescence probes for fluorescence microscopy imaging. Furthermore, the introduction of Gd3+made the nanoparticles effective contrast agents when applied in contrast-enhanced magnetic resonance (MR) imaging because they could improve the contrast of MR imaging. The excellent biocompatibility of these nanoparticles, as demonstrated via a typical CCK-8 assay, and their performance in fluorescence cell imaging and MR imaging shows their potential for applications in biomedical imaging.