The Effect of Cortisol on Recovery from Exhaustive Exercise in Rainbow Trout (Oncorhynchus mykiss): Potential Mechanisms of Action
The Effect of Cortisol on Recovery from Exhaustive Exercise in Rainbow Trout (Oncorhynchus mykiss): Potential Mechanisms of Action
复制标题
皮质醇对虹鳟 (Oncorhynchus mykiss) 力竭运动恢复的影响：潜在的作用机制
DOI：
10.1086/physzool.69.5.30164253
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
C. Milligan
中科院分区：
文献类型：
--
作者：
S. Eros;C. Milligan
研究了皮质醇对虹鳟鱼力竭运动后代谢恢复的影响及其可能的作用机制。当运动后皮质醇的上升是防止在鱼中通过阻止皮质醇合成与甲吡酮或皮质醇释放与地塞米松，有一个更快的恢复血液和肌肉代谢产物和酸碱状态，在这些鱼比在控制鱼。为了研究防止血浆皮质醇升高是否是这些效应的原因，进行了两个实验。用甲吡酮处理的鱼注入皮质醇后，恢复率恢复到对照鱼的水平。治疗与11-脱氧皮质醇或脱氧皮质酮，皮质醇生物合成途径的中间体，其水平可能会增加甲吡酮治疗，并没有增加恢复率;事实上，血浆皮质醇升高，恢复延长鱼与11-脱氧皮质醇治疗。这些实验表明，防止运动后血浆皮质醇升高与减少代谢和酸碱恢复所需的时间有关。皮质醇的作用机制不是鳃净酸排泄的改变，也不是由RU 486敏感性皮质醇受体的某些作用介导的。这表明，皮质醇可能发挥适应性作用，从力竭运动的恢复提供乳酸作为运动后有氧燃料。
The effects of cortisol on metabolic recovery from exhaustive exercise in rainbow trout (Oncorhynchus mykiss) and potential mechanisms of action were investigated. When the postexercise rise in cortisol is prevented in fish by blocking either cortisol synthesis with metyrapone or cortisol release with dexamethasone, there is a faster recovery of blood and muscle metabolites and acid-base status in those fish than in control fish. To investigate whether preventing the rise in plasma cortisol is responsible for these effects, two experiments were done. Cortisol infused intofish treated with metyrapone returned the rate of recovery to that of control fish. Treatment with 11-deoxycortisol or deoxycorticosterone, intermediates in the cortisol biosynthetic pathway, the levels of which are possibly increased by metyrapone treatment, did not increase the rate of recovery; indeed, plasma cortisol was elevated and recovery prolonged in fish treated with 11-deoxycortisol. These experiments indicate that preventing the postexercise rise in plasma cortisol is associated with decreasing the time required for metabolic and acid-base recovery. The mechanism of cortisol action is not alteration of net acid excretion at the gills or mediated by some action at the RU486-sensitive cortisol receptor. It is suggested that cortisol may play an adaptive role in recovery from exhaustive exercise by providing lactate as a postexercise aerobic fuel.