The aetiology of transient global amnesia. A case-control study of 114 cases with prospective follow-up.
The aetiology of transient global amnesia. A case-control study of 114 cases with prospective follow-up.
复制标题
短暂性全面遗忘症的病因学。
DOI：
--
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
C. Warlow
中科院分区：
文献类型：
--
作者：
J. Hodges;C. Warlow
对114例短暂性全面遗忘症（TGA）患者进行了病例对照比较，其中包括正常社区对照组（n = 109）和短暂性脑缺血发作（TIA）对照组（n = 212），结果显示，没有证据表明TGA风险增加与任何传统的脑血管疾病风险因素相关。然而，偏头痛在TGA患者中明显比对照组更常见。一项采用精算（生命表）分析的前瞻性纵向研究证实，TGA患者的预后明显优于TIA对照组。重要的少数（7%）TGA病例通常在发病后一年内出现癫痫。根据这些证据，可以确信地拒绝TGA的血栓栓塞病因，至少对于绝大多数病例是这样。有很好的理论理由将偏头痛和TGA随意联系起来，偶尔癫痫可能伪装成TGA。其余病例的原因仍然不明。
A case-control comparison of 114 transient global amnesia (TGA) patients using both normal community-based controls (n = 109) and transient ischaemic attack (TIA) controls (n = 212) showed no evidence of an increased risk of TGA associated with any of the conventional risk factors for cerebrovascular disease. However, migraine was significantly more common in the TGA patients than in either control group. A prospective longitudinal study using actuarial (life table) analysis confirmed that the prognosis of the TGA patients was strikingly better than that of the TIA controls. An important minority (7%) of TGA cases developed epilepsy, usually within one year of presentation. On the basis of this evidence, a thromboembolic aetiology for TGA can be confidently rejected, at least for the vast majority of cases. There are good theoretical reasons to link migraine and TGA casually, and occasionally epilepsy may masquerade as TGA. In the remaining cases the cause remains unknown.