The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair
The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair
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DOI：
10.1038/sj.onc.1208560
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发表时间：
2005-08-11
期刊：
影响因子：
8
通讯作者：
Werner, S
中科院分区：
文献类型：
--
作者：
Beer, HD;Bittner, M;Werner, S
成纤维细胞生长因子结合蛋白（FGF-BP）结合并激活FGF-1和FGF-2，从而促进肿瘤血管生成。在这项研究中，我们确定了FGF-BP的新的结合伙伴，我们提供了证据，这种蛋白质在上皮修复过程中的作用。我们发现，FGF-BP的表达增加后，小鼠和人的皮肤损伤，特别是在角质形成细胞。这种上调最有可能通过伤口部位存在的主要角质细胞有丝分裂原实现。最重要的是，我们证明了FGF-BP与FGF-7，FGF-10和最近鉴定的FGF-22相互作用，并增强低浓度配体的活性。由于FGF-7和FGF-10对损伤上皮修复的重要功能，我们的研究结果表明，损伤后FGF-BP表达的上调刺激伤口部位的FGF活性，从而增强上皮修复的过程。
The fibroblast growth factor-binding protein (FGF-BP) binds and activates FGF-1 and FGF-2, thereby contributing to tumor angiogenesis. In this study, we identified novel binding partners of FGF-BP, and we provide evidence for a role of this protein in epithelial repair processes. We show that expression of FGF-BP increases after injury to murine and human skin, in particular in keratinocytes. This upregulation is most likely achieved by major keratinocyte mitogens present at the wound site. Most importantly, we demonstrate that FGF-BP interacts with FGF-7, FGF-10, and with the recently identified FGF-22, and enhances the activity of low concentrations of ligand. Due to the important functions of FGF-7 and FGF-10 for repair of injured epithelia, our findings suggest that upregulation of FGF-BP expression after injury stimulates FGF activity at the wound site, thus enhancing the process of epithelial repair.