A case report of recurrent Merkel cell carcinoma with synchronous metastases to the heart and stomach.
A case report of recurrent Merkel cell carcinoma with synchronous metastases to the heart and stomach.
复制标题
复发性默克尔细胞癌的病例报告，与心脏和胃同步转移。
DOI：
10.1097/md.0000000000013032
复制
发表时间：
2018-11
期刊：
影响因子：
1.6
通讯作者：
Hwang IG
中科院分区：
文献类型：
--
作者：
Ha JY;Park SE;Kim HS;Won H;Kim BJ;Hwang IG
默克尔细胞癌（MCC）是一种侵袭性、罕见的神经内分泌皮肤癌。MCC转移到心脏是非常罕见的，而由MCC转移到胃也很少有报道。我们描述了一个82岁的男性诊断为复发性MCC并心脏和胃转移的病例，他表现为口服摄入不良和严重的体重减轻。患者3年前被诊断为MCC，并接受手术切除和放射治疗。我们对水肿病变行胃活检。超声引导下行心脏肿块穿刺活检。MCC同时转移到心脏和胃。原发病变完全消退，患者每6个月定期随访2年半，无疾病。MCC复发后，考虑姑息性抗癌治疗，但由于患者体能状况不佳，涉及老年人，合并复发性肺炎，无法进行姑息性抗癌治疗。据我们所知，这是世界上首例皮肤MCC同时发生心脏和胃转移的报道。虽然罕见，但在临床病例中应考虑到MCC的同步转移。
Merkel cell carcinoma (MCC) is an aggressive, rare neuroendocrine skin cancer. MCC metastasis to the heart is exceedingly rare and gastric metastases from MCC have rarely been reported. We described the case of an 82-year-old man diagnosed with recurrent MCC with cardiac and gastric metastasis who presented with poor oral intake and severe weight loss. The patient was diagnosed with MCC 3 years ago and treated with surgical resection and radiation. We performed stomach biopsy in edematous lesion. And fluoroscopy and ultrasound guided biopsy of the cardiac mass was performed. MCC with synchronous metastases to the heart and stomach. The primary lesion had complete resolution and the patient remained disease free on regular follow-up every 6 months for 2 and half years. After MCC recurred, palliative anti-cancer therapy was considered but could not be performed due to the patient's poor performance status involved elderly, combined recurrent pneumonia. To our best knowledge, this is the first report of synchronous cardiac and gastric metastasis from cutaneous MCC worldwide. Although uncommon, MCC should be considered in clinical cases of synchronous metastasis.