Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing.
Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing.
复制标题
DOI：
10.1158/1078-0432.ccr-12-0315
复制
发表时间：
2012-08-15
期刊：
影响因子：
--
通讯作者：
Hruban RH
中科院分区：
文献类型：
--
作者：
Iacobuzio-Donahue CA;Velculescu VE;Wolfgang CL;Hruban RH
胰腺癌是由特定癌症相关基因的遗传性和获得性突变引起的。胰腺癌中最常见的基因改变的发现不仅提供了对驱动从正常细胞发展到非侵入性前体病变再到广泛转移性疾病的基本途径的深入了解，而且最近的基因发现也为基于基因的胰腺肿瘤早期检测、个性化治疗和分子分类方法开辟了新的机会。
Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has not only provided insight into the fundamental pathways driving the progression from a normal cell, to non-invasive precursor lesions, to widely metastatic disease, but recent genetic discoveries have also opened new opportunities for gene-based approaches to early detection, personalized treatment, and molecular classification of pancreatic neoplasms.