Nanoconfinement Effects on the Glass Transition and Crystallization Behaviors of Nifedipine
Nanoconfinement Effects on the Glass Transition and Crystallization Behaviors of Nifedipine
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DOI：
10.1021/acs.molpharmaceut.8b01172
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发表时间：
2019-02-01
影响因子：
4.9
通讯作者：
McKenna, Gregory B.
中科院分区：
文献类型：
--
作者：
Cheng, Sixue;McKenna, Gregory B.
用差示扫描量热法研究了纳米限制对硝苯地平(NIF)晶化和玻璃化转变行为的影响。纳米约束是通过将NIF吸收到多孔介质(受控孔玻璃，CPG)中来提供的，并将结果与非约束块状材料进行了比较。与文献结果一致，玻璃化转变温度T-g和熔化温度T-m都随着孔径的减小而降低。熔融温度随孔径倒数的增加而降低，可用Gibbs-Thomson方程进行分析。此外，对于7.5 nm和12 nm的限制尺寸，发现从玻璃态加热到预期熔化转变以上时没有发生冷结晶。最后，在中间禁闭时，我们发现了一种可能的新的禁闭诱导的NIF多态的证据。
The impact of nanoconfinement on the crystallization and glass transition behaviors of nifedipine (NIF) has been investigated using differential scanning calorimetry. Nanoconfinement was provided by imbibing the NIF into a porous medium (controlled pore glass, CPG), and results were compared with the unconfined bulk material. Consistent with previous results from the literature, both glass transition temperature T-g and melting temperature T-m decrease with decreasing pore size. The melting temperature was found to decrease with the reciprocal of pore diameter and could be analyzed with the Gibbs-Thomson equation. In addition, for confinement sizes of 7.5 and 12 nm, it was found that no cold-crystallization occurs upon heating from the glassy state to above the expected melting transition. Finally, at intermediate confinements we find evidence of a possible new, confinement-induced polymorph of NIF.