Controllable structure, properties, and degradation of the electrospun PLGA/PLA-blended nanofibrous scaffolds
Controllable structure, properties, and degradation of the electrospun PLGA/PLA-blended nanofibrous scaffolds
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DOI：
10.1002/app.36757
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发表时间：
2012-09-25
影响因子：
3
通讯作者：
Qi, Ning
中科院分区：
文献类型：
--
作者：
Liu, Hua;Wang, Shudong;Qi, Ning
本研究采用静电纺丝法成功制备了PLGA/PLA共混纳米纤维。通过SEM、FTIR、DSC、TG、接触角、Instron拉伸试验机和降解测试等手段对电纺PLGA/PLA纳米纤维支架的宏观结构、热稳定性、亲水性、力学性能和体外降解进行表征。结果表明，电纺 PLGA/PLA 共混纳米纤维支架具有纳米纤维和多孔结构。电纺PLGA/PLA共混纳米纤维支架的结构稳定性、结晶度、润湿性和机械性能，特别是体外降解率，可以通过调节聚丙交酯-乙交酯(PLGA)和聚丙交酯(PLA)的混合比例来控制。结果表明，电纺 PLGA/PLA 共混纳米纤维支架可被视为组织工程支架的理想候选材料。(C) 2012 Wiley periodicals, Inc. J Appl Polym Sci, 2012
In this research, the PLGA/PLA-blended nanofibers were successfully prepared by electrospinning. The macromicro structure, thermal stability, hydrophilicity, mechanical properties, and in vitro degradation of the electrospun PLGA/PLA nanofibrous scaffolds are characterized by means of SEM, FTIR, DSC, TG, contact angle, instron tensile tester, and degradation testing. The results showed that electrospun PLGA/PLA-blended nanofibrous scaffolds possessed nanofibrous and porous structures. The structural stability, crystallinity, wettability, and mechanical properties, especially the in vitro degradation rate, of the electrospun PLGA/PLA-blended nanofibrous scaffolds could be controlled by regulating the blended ratio of the poly(lactide-co-glycolide) (PLGA) and poly(lactide) (PLA). The results indicated that the electrospun PLGA/PLA-blended nanofibrous scaffolds could be considered as ideal candidates for tissue engineering scaffolds.(C) 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012