Tissue engineering strategies for bone regeneration
Tissue engineering strategies for bone regeneration
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DOI：
10.1007/b99997
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Mikos, AG
中科院分区：
文献类型：
--
作者：
Mistry, AS;Mikos, AG
由于创伤或疾病引起的骨丢失是一个日益严重的健康问题。由于骨组织的复杂解剖学和生理学以及医疗技术的局限性，目前对临界尺寸缺损的临床治疗存在问题，并且通常愈合不良。骨组织工程是利用人体对组织损伤的自然生物学反应，结合工程学原理，为严重骨损伤的治疗提供了一种有前途的替代策略。成骨细胞、生长因子和生物材料支架形成了许多骨组织工程策略的基础，这些策略用于实现受损组织的修复和恢复。理想的生物材料支架将为受伤部位提供机械支撑，并将生长因子和细胞输送到缺损处以促进组织生长。此外，这种生物材料应该以受控的方式降解，而不会引起显著的炎症反应。下一章重点介绍了骨组织再生研究各个领域的多种策略和最新进展。
Bone loss due to trauma or disease is an increasingly serious health problem. Current clinical treatments for critical-sized defects are problematic and often yield poor healing due to the complicated anatomy and physiology of bone tissue, as well as the limitations of medical technology. Bone tissue engineering offers a promising alternative strategy of healing severe bone injuries by utilizing the body's natural biological response to tissue damage in conjunction with engineering principles. Osteogenic cells, growth factors, and biomaterial scaffolds form the foundation of the many bone tissue engineering strategies employed to achieve repair and restoration of damaged tissue. An ideal biomaterial scaffold will provide mechanical support to an injured site and also deliver growth factors and cells into a defect to encourage tissue growth. Additionally, this biomaterial should degrade in a controlled manner without causing a significant inflammatory response. The following chapter highlights multiple strategies and the most recent advances in various areas of research for bone tissue regeneration.