Utility of Nonhuman Primates in Substance Use Disorders Research
Utility of Nonhuman Primates in Substance Use Disorders Research
复制标题
DOI：
10.1093/ilar/ilx014
复制
发表时间：
2017-01-01
期刊：
影响因子：
2.5
通讯作者：
Negus, Sidney S.
中科院分区：
文献类型：
--
作者：
Banks, Matthew L.;Czoty, Paul W.;Negus, Sidney S.
物质使用障碍（即，吸毒成瘾）构成了一个全球性的潜在公共卫生问题。临床前生物医学研究在阐明药物滥用的环境、生物学和药理学决定因素以及开发创新的药理学和行为治疗策略的过程中具有非常宝贵的价值。70多年来，非人灵长类动物一直被用作与药物成瘾相关的生物医学研究的研究对象。已经有几篇优秀的已发表综述强调了临床前药物滥用研究中啮齿动物和非人灵长类动物之间药效学和药代动力学的种属差异。因此，本综述的目的是强调非人灵长类动物作为临床前药物滥用研究对象的三个优势。首先，与其他实验室动物相比，非人灵长类动物在实验设计方面具有技术优势，为促进临床前到临床转化研究提供了独特的机会。其次，这些技术优势，加上非人灵长类动物相对较长的寿命，允许配对纵向药物自我管理研究和非侵入性成像技术，以阐明慢性药物暴露的生物学后果。最后，非人灵长类动物在静脉药物自我给药模式方面具有优势，这对物质使用障碍病因学的神经生物学机制和物质使用障碍药物治疗的药物开发过程具有潜在的理论意义。我们的结论与潜在的未来研究方向，非人灵长类动物将提供独特的和有价值的见解滥用和成瘾的新型精神活性物质。
Substance use disorders (i.e., drug addiction) constitute a global and insidious public health issue. Preclinical biomedical research has been invaluable in elucidating the environmental, biological, and pharmacological determinants of drug abuse and in the process of developing innovative pharmacological and behavioral treatment strategies. For more than 70 years, nonhuman primates have been utilized as research subjects in biomedical research related to drug addiction. There are already several excellent published reviews highlighting species differences in both pharmacodynamics and pharmacokinetics between rodents and nonhuman primates in preclinical substance abuse research. Therefore, the aim of this review is to highlight three advantages of nonhuman primates as preclinical substance abuse research subjects. First, nonhuman primates offer technical advantages in experimental design compared to other laboratory animals that afford unique opportunities to promote preclinical-to-clinical translational research. Second, these technical advantages, coupled with the relatively long lifespan of nonhuman primates, allows for pairing longitudinal drug self-administration studies and noninvasive imaging technologies to elucidate the biological consequences of chronic drug exposure. Lastly, nonhuman primates offer advantages in the patterns of intravenous drug self-administration that have potential theoretical implications for both the neurobiological mechanisms of substance use disorder etiology and in the drug development process of pharmacotherapies for substance use disorders. We conclude with potential future research directions in which nonhuman primates would provide unique and valuable insights into the abuse of and addiction to novel psychoactive substances.