Evaluation of a new system for ventilatory administration of nitric oxide
Evaluation of a new system for ventilatory administration of nitric oxide
复制标题
一氧化氮通气管理新系统的评估
DOI：
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发表时间：
1993
影响因子：
2.1
通讯作者：
S. Lundin
中科院分区：
文献类型：
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作者：
O. Stenqvist;B. Kjelltoft;S. Lundin
介绍了一种由两个质量流量调节器和一个清除二氧化氮（NO2）的钠石灰吸收器组成的新型一氧化氮（NO）吸入系统。使用三种不同的NO分析技术（红外、化学发光和电化学燃料电池技术）对该系统进行了评估。电化学燃料电池对样品湿度的敏感性较低，适合临床常规使用。红外分析仪对湿度非常敏感，气体样品必须用硅胶干燥，硅胶会吸收NO2，导致NO2值虚低。用紫外分光光度法分析二氧化氮。二氧化氮有剧毒，建议吸入的最高职业健康和安全水平为5ppm。我们的系统中NO2的最高值是在吸收体之前在呼吸系统的吸气肢体中检测到的，在100%氧气下为5 ppm，在“婴儿”呼吸设置下为100 ppm（通气31 /min，频率30/min）。“成人”呼吸设置（通气10 1/min，频率15/min）的相应值为3.2 ppm。吸收剂将这些水平降低到远低于1ppm。当使用临床相关的NO水平（20 ppm）时，无论呼吸气体中的氧气浓度如何，吸收器后都无法检测到NO2。据观察，氮气和NO混合的气瓶最初可能有很高的NO2浓度（约12 ppm），在使用前应彻底冲洗。
A new system for delivery of nitric oxide (NO) to inspiratory gas consisting of two mass flow regulators and a soda–lime absorber for scavenging of nitrogen dioxide (NO2) is described. The system was evaluated using three different techniques for NO analysis (infrared, chemi–luminescence and electro–chemical fuel cell technique). The electro–chemical fuel cell was less sensitive to humidity in the sample and is suitable for clinical routine use. The infrared analyser was very sensitive to humidity and the gas sample must be dried by silica gel, which absorbs NO2 and will cause falsely low NO2 values. NO2 was analysed with ultra–violet methodology. NO2 is highly toxic and the highest recommended occupational health and safety level for inhalation is 5 ppm. The highest values of NO2 in our system were detected before the absorber in the inspiratory limb of the breathing system, being 5 ppm at 100% oxygen and 100 ppm NO using “infant” respiratory settings (3 1/min in ventilation, frequency of 30/min). The corresponding value for “adult” respiratory settings (10 1/min in ventilation, frequency of 15/min) was 3.2 ppm. The absorber reduced these levels to well below 1 ppm. When clinically relevant levels of NO were used (20 ppm), no NO2 could be detected after the absorber, irrespective of oxygen concentration in the breathing gas. It was observed that gas cylinders with NO mixed in nitrogen may initially have a high NO2 concentration (around 12 ppm) and should be flushed thoroughly before use.