Novel compounds active against Leishmania major.
Novel compounds active against Leishmania major.
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新型化合物对利什曼原虫具有活性。
DOI：
10.1128/aac.50.2.474-479.2006
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
Selitrennikoff,ClaudeP
中科院分区：
文献类型：
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作者：
StGeorge,Stephanie;Bishop,JeanetteV;Titus,RichardG;Selitrennikoff,ClaudeP
主要利什曼原虫是一种重要的锥虫病原体，导致利什曼病，这是一种严重的疾病，在许多旧世界。目前的治疗方法包括少量的锑化合物，虽然有些有效，但受到严重副作用的限制。我们已经筛选了一个独特的化学库的一小部分，并发现了至少三个新的化合物，是有效的。tarentolaeandL.主要在体外和小鼠巨噬细胞模型中的L.严重感染这些化合物在显著低于葡萄糖酸锑钠（Pentoclavine）的剂量下在两种测定中均有效，代表了药物开发的可能候选物。
Leishmania majoris an important trypanosomatid pathogen that causes leishmaniasis, which is a serious disease in much of the Old World. Current treatments include a small number of antimony compounds that, while somewhat effective, are limited by serious side effects. We have screened a small portion of a unique chemical library and have found at least three novel compounds that are effective againstL. tarentolaeandL. majorin vitro and in a murine macrophage model ofL. majorinfection. These compounds were effective in both assays at doses significantly lower than those of sodium stibogluconate (Pentostam) and represent possible candidates for drug development.