White Blood Cell Counts, Leukocyte Ratios, and Eosinophils as Inflammatory Markers in Patients With Coronary Artery Disease
White Blood Cell Counts, Leukocyte Ratios, and Eosinophils as Inflammatory Markers in Patients With Coronary Artery Disease
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DOI：
10.1177/1076029614531449
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发表时间：
2015-03-01
影响因子：
2.9
通讯作者：
Hahalis, George
中科院分区：
文献类型：
--
作者：
Kounis, Nicholas G.;Soufras, George D.;Hahalis, George
炎症是动脉粥样硬化及其临床表现的关键特征。白细胞计数已成为临床实践中广泛使用的炎症标志物。由于炎症在动脉粥样硬化及其最终结果中起着关键作用，因此发现新的炎症生物标志物变得重要，以帮助诊断准确性并提供有关冠心病的预后信息。在急性冠状动脉综合征和经皮冠状动脉介入治疗中，几乎所有白色血细胞计数亚型（包括嗜酸性粒细胞、单核细胞、中性粒细胞和淋巴细胞）以及嗜酸性粒细胞-淋巴细胞比率和嗜酸性粒细胞-白细胞比率水平升高构成不良结局的独立预测因素。特别是嗜酸性粒细胞计数和嗜酸性粒细胞-白细胞比率，成为冠状动脉疾病患者危险分层的新生物标志物。由于嗜酸性粒细胞的存在表示与Kounis综合征相关的超敏性炎症和超敏反应，因此这一事实对于阐明炎症的病因以考虑预测和预防措施并应用适当的治疗方法至关重要。
Inflammation is a key feature of atherosclerosis and its clinical manifestations. The leukocyte count has emerged as a marker of inflammation that is widely available in clinical practice. Since inflammation plays a key role in atherosclerosis and its end results, discovering new biomarkers of inflammation becomes important in order to help diagnostic accuracy and provide prognostic information about coronary cardiac disease. In acute coronary syndromes and percutaneous coronary intervention, elevated levels of almost all subtypes of white blood cell counts, including eosinophils, monocytes, neutrophils, and lymphocytes, and neutrophil-lymphocyte ratio and eosinophil-leukocyte ratio constitute independent predictors of adverse outcomes. Eosinophil count and eosinophil-leukocyte ratio, in particular, emerge as novel biomarkers for risk stratification in patients with coronary artery disease. Since the presence of eosinophils denotes hypersensitivity inflammation and hypersensitivity associated with Kounis syndrome, this reality is essential for elucidating the etiology of inflammation in order to consider predictive and preventive measures and to apply the appropriate therapeutic methods.