Mode of infant feeding and HIV infection in children in a program for prevention of mother-to-child transmission in Uganda
Mode of infant feeding and HIV infection in children in a program for prevention of mother-to-child transmission in Uganda
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DOI：
10.1097/01.aids.0000161773.29029.c0
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发表时间：
2005-03-04
期刊：
影响因子：
3.8
通讯作者：
Vella, S
中科院分区：
文献类型：
--
作者：
Magoni, M;Bassani, L;Vella, S
目的：为了评估不同的婴儿喂养方式对艾滋病毒传播的影响，在预防母婴传播（PMTCT）计划在城市hospitalinUganda.Methods：艾滋病毒感染的孕妇在预防母婴传播计划在圣弗朗西斯医院Nsambya，坎帕拉提供了机会参加这项研究。向选择不进行母乳喂养的妇女免费提供短期抗逆转录病毒疗法和配方奶喂养。对母婴进行随访，直至产后6个月。在第6周和第6个月评估儿童的艾滋病毒状况。根据婴儿喂养方式将母婴配对分为纯配方奶粉喂养组（EFF）、纯母乳喂养组（EBF）和混合喂养组（MF）。第6周的传播率为8.9%（EFF组为3.4%，EBF组为11.2%，MF组为17.1%），第6个月为12.0%（EFF组为3.7%，EBF组为16.0%，MF组为20.4%）。与EFF组相比，EBF和MF组的HIV传播风险显著更高。EBF和MF groups.Conclusions之间没有显着的风险差异，观察到：艾滋病毒的传播率显着降低配方奶粉喂养的婴儿相比，纯母乳喂养和混合喂养的婴儿。通过母乳喂养的传播似乎主要发生在分娩后的头几周。(c)2005年利平科特威廉姆斯&威尔金斯。
Objective: To evaluate the impact of different modalities of infant feeding on HIV transmission in children in a prevention of mother-to-child transmission (PMTCT) program in an urban hospital in Uganda.Methods: HIV-infected pregnant women in the PMTCT program at St Francis Hospital Nsambya, Kampala were offered the chance to participate in the study. Short-course antiretroviral regimens were provided and formula feeding offered free of charge for women choosing not to breastfeed. Mother-infant pairs were followed until 6 months postpartum. HIV status in children was assessed at week 6 and month 6. For the analyses, mother-infant pairs were classified into three groups according to the mode of infant feeding: exclusive formula feeding (EFF), exclusive breastfeeding (EBF) and mixed feeding (MF).Results: A total of 306 children were enrolled. Transmission rates were 8.9% at week 6 (3.4% in the EFF group, 11.2% in the EBF group, 17.1% in the MF group) and 12.0% at month 6 (3.7% in the EFF group, 16.0% in the EBF group, and 20.4% in the MF group). The EBF and MF groups were associated with a significantly higher risk of HIV transmission than the EFF group. No significant risk difference was observed between the EBF and the MF groups.Conclusions: HIV transmission rates were significantly lower in formula-fed infants in comparison with both exclusively breastfed and mixed-fed infants. Transmission through breastfeeding seems to occur mainly in the first weeks after delivery. (c) 2005 Lippincott Williams & Wilkins.