Redox regulation of cell migration and adhesion.
Redox regulation of cell migration and adhesion.
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DOI：
10.1016/j.tcb.2011.11.002
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发表时间：
2012-02
影响因子：
19
通讯作者：
Lehmann R
中科院分区：
文献类型：
--
作者：
Hurd TR;DeGennaro M;Lehmann R
活性氧（ROS），特别是过氧化氢，及其调控蛋白在细胞的迁移和粘附中起着重要作用。生长因子和化学引诱剂刺激细胞表面受体产生ROS，将细胞表面的信号传递给细胞内的关键信号蛋白。ROS在细胞内促进迁移，也在非迁移细胞中影响迁移细胞的行为。过氧化氢本身也被认为是一种化学引诱剂，将免疫细胞吸引到伤口上。我们讨论了在细胞迁移和粘附的相关过程中，生物体如何使用活性氧以及它们在多大程度上依赖活性氧的最新进展。
Reactive oxygen species (ROS), particularly hydrogen peroxide, and the proteins that regulate them play important roles in the migration and adhesion of cells. Stimulation of cell surface receptors with growth factors and chemoattractants generates ROS, which relay signals from the cell surface to key signaling proteins inside the cell. ROS act within cells to promote migration and also in nonmigrating cells to influence the behavior of migrating cells. Hydrogen peroxide has also been suggested to act as a chemoattractant in its own right, drawing immune cells to wounds. We discuss recent progress made towards understanding how organisms use ROS, and to what degree they depend on them, during the related processes of cell migration and adhesion.