The role of allogeneic epidermis in murine graft rejection.
The role of allogeneic epidermis in murine graft rejection.
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DOI：
10.1097/00004630-198903000-00009
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发表时间：
1989-03-01
期刊：
影响因子：
--
通讯作者：
Hull, B E
中科院分区：
文献类型：
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作者：
Lerner-Tung, M B;Hull, B E
在胶原基质中含有同种异体成纤维细胞并覆盖同种表皮细胞的皮肤等同物已成功移植到啮齿动物身上。相比之下，含有同种异体成纤维细胞和同种异体表皮细胞的皮肤替代物会引起强烈的排斥反应，其特征是在移植后1周单核细胞渗入表皮，2周后淋巴细胞阻断微血管并破坏表皮。基于这些发现，含有同种异体成纤维细胞的皮肤等效物可用于烧伤的治疗，但表皮应从患者身上获取。
Skin equivalents containing allogeneic fibroblasts in a collagen matrix and overlaid with isologous epidermal cells have been successfully grafted to rodents. By contrast, skin equivalents containing isologous fibroblasts and allogeneic epidermal cells provoke a strong rejection response, characterized by the infiltration of mononuclear cells into the epidermis at 1 week and occlusion of the microvasculature and destruction of the epidermis by lymphocytes 2 weeks after grafting. Based on these findings, skin equivalents containing allogeneic fibroblasts could be used in the treatment of burn injuries, but the epidermis should be obtained from the patient.