Human papillomaviruses target differentiating epithelia for virion production and malignant conversion
Human papillomaviruses target differentiating epithelia for virion production and malignant conversion
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人乳头瘤病毒靶向分化上皮细胞以产生病毒颗粒和恶性转化
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发表时间：
1996
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影响因子：
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通讯作者：
L. Laimins
中科院分区：
文献类型：
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作者：
L. Laimins
摘要 人乳头瘤病毒感染复层上皮细胞并诱导过度增殖性病变。已鉴定出 70 多种不同的 HPV 类型，每种类型都针对不同身体部位的上皮细胞。包括 HPV 16、18、31、45 和 54 型在内的一个子集以生殖道为目标，是宫颈癌的病因。虽然病毒感染是大多数宫颈癌发生的必要先决条件，但其本身并不足以表明还需要二次突变事件。病毒生命与上皮分化密切相关，并且该过程在恶性肿瘤的发展过程中被破坏。在生产性感染中，病毒体的营养复制和产生仅限于高度分化的基底上细胞。对分化上皮细胞中病毒生命周期的调节机制的分析可以深入了解为什么某些类型会诱发生殖道癌症。
Abstract Human papillomaviruses infect stratified epithelial cells and induce hyperproliferative lesions. Over 70 different HPV types have been identified and each targets epithelia at distinct body locations. A subset, including HPV types 16, 18, 31, 45 and 54, target the genital tract and are the etiological agents of cervical cancers. While viral infection is a necessary prerequisite for the development of most cervical cancers, it is not by itself sufficient indicating that secondary mutational events are also required. The viral life is closely linked to epithelial differentiation and this process is disrupted in the development of malignancies. In a productive infection, vegetative replication and production of virions is restricted to highly differentiated suprabasal cells. Analysis of the mechanisms regulating the viral life cycle in differentiating epithelia provides insight into why certain types induce cancers of the genital tract.