Abnormal amphiregulin expression correlates with gastric cancer prognosis.
Abnormal amphiregulin expression correlates with gastric cancer prognosis.
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DOI：
10.18632/oncotarget.12436
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发表时间：
2016-11-22
期刊：
影响因子：
--
通讯作者：
Feng Z
中科院分区：
文献类型：
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作者：
Wang B;Yong H;Zhu H;Ni D;Tang S;Zhang S;Wang W;Zhou Y;Zhao W;Ding G;Zhu J;Li X;Feng Z
胃癌（GC）是一个全球性的健康问题，死亡率很高.由于缺乏可靠的工具，GC的早期诊断和跟踪是一个挑战。双调蛋白（AREG）是表皮生长因子（EGF）家族的成员，在结合EGF受体时激活生长信号。AREG表达升高与各种病理状况相关，包括癌症。在这里，我们研究了AREG表达增加是否是GC的疾病指标和/或预后生物标志物。我们使用组织微阵列和定量实时聚合酶链反应来评估AREG在GC的各个阶段的临床组织标本中的表达，并进行生物信息学分析来评估AREG过表达作为GC生物标志物的价值。我们发现，无论是mRNA和蛋白质表达的胃癌患者的组织相比，从非癌症患者或正常组织中增加。AREG的高表达与胃癌的临床病理特征及生存率相关。因此，AREG的过表达可以作为一种新的GC生物标志物，并且其表达的主动监测可以是GC诊断和监测的新方法。
Gastric cancer (GC) is a global health issue with a high mortality rate. Early diagnosis and tracking of GC is a challenge due to a lack of reliable tools. Amphiregulin (AREG) is a member of the epidermal growth factor (EGF) family that activates growth signaling upon binding of EGF receptors. Elevated AREG expression is associated with various pathological conditions, including cancer. Here, we investigated whether increased AREG expression is a disease indicator and/or prognostic biomarker for GC. We used tissue microarray and quantitative real-time polymerase chain reaction to assess AREG expression in clinical tissue specimens at various stages of GC and a conducted bioinformatics analysis to evaluate the value of AREG over-expression as a GC biomarker. We found that both mRNA and protein expression of AREG were increased in the tissues of GC patients when compared to tissues from non-cancer patients or normal tissues. High expression of AREG was also associated with GC clinicopathological characteristics and poor survival. Thus, over-expression of AREG could serve as a novel GC biomarker, and active surveillance of its expression could be a novel approach to GC diagnosis and monitoring.