Remyelination is extensive in a subset of multiple sclerosis patients
Remyelination is extensive in a subset of multiple sclerosis patients
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DOI：
10.1093/brain/awl217
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发表时间：
2006-12-01
期刊：
影响因子：
14.5
通讯作者：
Lassmann, Hans
中科院分区：
文献类型：
--
作者：
Patrikios, Peter;Stadelmann, Christine;Lassmann, Hans
虽然自发性髓鞘再生确实发生在多发性硬化症病变中，但其在全球多发性硬化症患者中的程度目前尚不清楚。我们系统地分析了51例具有不同临床病程和疾病持续时间的尸检患者的完全再髓鞘病变（所谓的阴影斑块）或部分再髓鞘病变（阴影斑块区域）的发生率和分布。不同病例的髓鞘再生程度不同。在20%的患者中，髓鞘再生的范围很广泛，60-96%的病变区域有髓鞘再生。广泛的髓鞘再生不仅见于复发性多发性硬化症患者，也见于部分进行性疾病患者。死亡年龄越大，病程越长，髓鞘再病变或病变区域明显增多。未发现髓鞘再生程度与发病时的性别或年龄相关。这些结果表明，在设计未来旨在促进中枢神经系统修复的临床试验时，必须考虑髓鞘再生的可变和患者依赖程度。
Although spontaneous remyelination does occur in multiple sclerosis lesions, its extent within the global population with this disease is presently unknown. We have systematically analysed the incidence and distribution of completely remyelinated lesions (so-called shadow plaques) or partially remyelinated lesions (shadow plaque areas) in 51 autopsies of patients with different clinical courses and disease durations. The extent of remyelination was variable between cases. In 20% of the patients, the extent of remyelination was extensive with 60-96% of the global lesion area remyelinated. Extensive remyelination was found not only in patients with relapsing multiple sclerosis, but also in a subset of patients with progressive disease. Older age at death and longer disease duration were associated with significantly more remyelinated lesions or lesion areas. No correlation was found between the extent of remyelination and either gender or age at disease onset. These results suggest that the variable and patient-dependent extent of remyelination must be considered in the design of future clinical trials aimed at promoting CNS repair.