Characteristics of Optic Disc Morphology in Glaucoma Patients with Parafoveal Scotoma Compared to Peripheral Scotoma
Characteristics of Optic Disc Morphology in Glaucoma Patients with Parafoveal Scotoma Compared to Peripheral Scotoma
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DOI：
10.1167/iovs.12-9908
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发表时间：
2012-07-01
影响因子：
4.4
通讯作者：
Park, Chan Kee
中科院分区：
文献类型：
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作者：
Jung, Kyoung In;Park, Hae-Young L.;Park, Chan Kee
目的。我们比较了旁中央暗点与周围暗点的视神经乳头（ONH）异常点的数量和位置以及视网膜神经纤维层（RNFL）的厚度。方法。如果平均偏差大于-10分贝(dB)，则总共招募35名正常眼压青光眼(NTG)患者，其在一个半视野10度半径内有孤立的中心凹旁暗点(PFS)，以及35名在一个半视野固定10度之外的鼻周边内有孤立的周边鼻台阶(PNS)的患者。比较两组通过海德堡视网膜断层扫描获得并通过 Moorfields 回归分析 (MRA) 分析的全局和扇区视盘立体参数，以及使用 Cirrus 谱域光学相干断层扫描测量的视网膜 RNFL 厚度。评估了上视野和下视野缺损的百分比。结果。在 PFS 中，上视场缺陷 (82.9%) 占主导地位，而 PNS 则显示下视场缺陷 (80.0%) 占主导地位。 PFS 组比 PNS 组显示出更小的边缘面积、更多的青光眼杯形状（分别为 P = 0.036、0.012）。在 MRA 分类中，PFS 组超出正常限度 (ONL) 的百分比更大 (P = 0.006)。与 PNS 组相比，PFS 组在视盘参数扇区分析中，颞区和颞下区表现出更多青光眼 ONH 形态，下象限、7 点钟和 8 点钟处的 RNFL 更薄（P 分别为 0.007、0.003、0.005）。结论。在早期 NTG 中，由于视盘边缘较窄且视杯较大，尤其是颞下区域，旁中央暗点可能比周围暗点更显着。 （投资眼科可见科学。2012 年；53：4813-4820）DOI：10.1167/iovs.12-9908
PURPOSE. We investigated the amount and location of optic nerve head (ONH) abnormal points and the retinal nerve fiber layer (RNFL) thickness with paracentral scotoma compared to peripheral scotoma.METHODS. Totals of 35 normal tension glaucoma (NTG) patients with isolated parafoveal scotoma (PFS) within a 10 degrees radius in one hemifield, and 35 patients with isolated peripheral nasal step (PNS) within the nasal periphery outside 10 degrees of fixation in one hemifield were enrolled if their mean deviation was greater than -10 decibels (dB). Global and sector optic disc stereometric parameters obtained by Heidelberg retina tomography and analyzed by Moorfields regression analysis (MRA), and retinal RNFL thickness measured using Cirrus spectral domain-optical coherence tomography were compared between the two groups. The percentages of superior and inferior field defects were evaluated.RESULTS. In PFS, superior field defects (82.9%) were found to be dominant, whereas PNS showed a predominance of inferior field defects (80.0%). The PFS group revealed smaller rim area, more glaucomatous cup shape than the PNS group (P = 0.036, 0.012, respectively). In MRA classification, the percentage outside of normal limits (ONL) was greater in the PFS group (P = 0.006). Compared to the PNS group, the PFS group exhibited more glaucomatous ONH morphology in the temporal and inferotemporal sectors in a sector analysis of optic disc parameters, and had thinner RNFLs in the inferior quadrant, and at 7 and 8 o'clock (P = 0.007, 0.003, 0.005, respectively).CONCLUSIONS. In early NTG, paracentral scotoma may be more significant than peripheral scotoma because of narrower optic disc rim and larger cup, especially inferotemporally. (Invest Ophthalmol Vis Sci. 2012;53:4813-4820) DOI:10.1167/iovs.12-9908