Posttraumatic stress disorder and the genetic structure of comorbidity.
Posttraumatic stress disorder and the genetic structure of comorbidity.
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创伤后应激障碍和共病的遗传结构。
DOI：
10.1037/a0019035
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发表时间：
2010
影响因子：
4.6
通讯作者：
Koenen,KarestanC
中科院分区：
文献类型：
--
作者：
Wolf,ErikaJ;Miller,MarkW;Krueger,RobertF;Lyons,MichaelJ;Tsuang,MingT;Koenen,KarestanC
本研究使用结构方程模型来检查内化和外化精神共病的潜在维度的遗传和环境结构，并探讨创伤后应激障碍（PTSD）与这些维度之间的结构关联。数据取自越南时代双胞胎登记处，包括 3,372 对男性对男性双胞胎的 PTSD 和一系列其他精神疾病的终生诊断。对这些疾病的表型结构的检查表明，创伤后应激障碍对内化和外化共同因素有交叉影响。生物特征分析表明，潜在的内化和外化共病维度的遗传风险因素在很大程度上是不同的，外化因素的总遗传力（69%）估计明显强于内化因素（41%）。非共享环境解释了内部化 (58%) 和外部化 (20%) 因素中剩余的大部分差异。两个维度上共有的遗传方差解释了 67% 的表型相关性 (r=. 52)。这些发现对于 PTSD 病因学的概念化及其在基于经验的疾病分类学中的定位具有重要意义。
This study used structural equation modeling to examine the genetic and environmental architecture of latent dimensions of internalizing and externalizing psychiatric comorbidity and explored structural associations between posttraumatic stress disorder (PTSD) and these dimensions. Data were drawn from the Vietnam Era Twin Registry and included lifetime diagnoses for PTSD and a range of other psychiatric disorders for 3,372 male–male twin pairs. Examination of the phenotypic structure of these disorders revealed that PTSD cross-loaded on both Internalizing and Externalizing common factors. Biometric analyses suggested largely distinct genetic risk factors for the latent internalizing and externalizing comorbidity dimensions, with the total heritability of the Externalizing factor (69%) estimated to be significantly stronger than that for Internalizing (41%). Nonshared environment explained the majority of the remaining variance in the Internalizing (58%) and Externalizing (20%) factors. Shared genetic variance across the 2 dimensions explained 67% of their phenotypic correlation (r=. 52). These findings have implications for conceptualizations of the etiology of PTSD and its location in an empirically based nosology.