Developmental regulation of cytokeratins in cells of the rat mammary gland studied with monoclonal antibodies.
Developmental regulation of cytokeratins in cells of the rat mammary gland studied with monoclonal antibodies.
复制标题
用单克隆抗体研究大鼠乳腺细胞中细胞角蛋白的发育调节。
DOI：
10.1073/pnas.81.4.1203
复制
发表时间：
1984
影响因子：
11.1
通讯作者：
Armstrong,B
中科院分区：
文献类型：
--
作者：
Allen,R;Dulbecco,R;Syka,P;Bowman,M;Armstrong,B
我们已经分离出两种抗细胞角蛋白的单克隆抗体，并确定了它们的细胞特异性。它们在大鼠乳腺内显示出有趣的定位。一种（1A 10）对肌上皮细胞具有特异性;另一种（24 B42）对不同发育阶段的内腔细胞具有特异性。这两个单克隆抗体和其他三个以前分离的细胞角蛋白与肌球蛋白和IV型胶原蛋白的抗体一起使用，以确认和扩展我们以前的研究结果上皮细胞类型和乳腺内的发展。
We have isolated two monoclonal antibodies to cytokeratins and determined their cell specificities. They display interesting localization within the rat mammary gland. One (1A10) shows specificity for myoepithelial cells; the other (24B42) is specific for lumenal cells at various stages of development. These two monoclonal antibodies and three others to cytokeratin previously isolated were used in conjunction with antibodies to myosin and collagen IV to confirm and extend our previous findings on epithelial cell types and development within the mammary gland.