Promoter evolution in BK virus: functional elements are created at sequence junctions.

Promoter evolution in BK virus: functional elements are created at sequence junctions.
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BK 病毒中的启动子进化:在序列连接处产生功能元件。

DOI:
10.1128/jvi.64.5.2411-2415.1990
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发表时间:
1990
影响因子:
5.4
通讯作者:
Dynan,WS
Dynan,WS
中科院分区:
医学2区
文献类型:
--
作者:
Markowitz,RB;Tolbert,S;Dynan,WS

文献摘要

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The archetypal strain of BK virus directed very little early gene expression compared with rearranged laboratory strains of the virus. One laboratory strain that was analyzed in detail contained newly created AP-1 binding enhancer modules spanning the junction between adjacent sequence repeats. Introduction of these sequences into the archetype activated the previously quiescent early promoter.