Exercise-induced changes in dendritic structure and complexity in the adult hippocampal dentate gyrus
Exercise-induced changes in dendritic structure and complexity in the adult hippocampal dentate gyrus
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DOI：
10.1016/j.neuroscience.2005.10.050
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发表时间：
2006-01-01
期刊：
影响因子：
3.3
通讯作者：
Christie, BR
中科院分区：
文献类型：
--
作者：
Redila, VA;Christie, BR
神经发生是成人齿状回的一种组成性活动，新细胞在颗粒下区产生，然后成为齿状回颗粒细胞层中的神经元。人们认为新的颗粒细胞在成熟时会从颗粒下区向外迁移到细胞层的边缘。在这些实验中，我们检查了具有低和高神经发生率的 Sprague-Dawley 大鼠的颗粒下区以及颗粒细胞区的内部和外部区域中颗粒细胞的树突形态。在神经发生率较低的动物中，位于颗粒下区的细胞的初级树突数量、树突复杂程度和树突总长度最低，内部颗粒细胞区神经元较高，外部颗粒细胞区颗粒细胞最高。颗粒下区颗粒细胞通常延伸一个初级树突并具有简单的、未成熟的树突树，而外部颗粒细胞区中的颗粒细胞具有增加的初级树突数量、更大的树突复杂性和更大的总树突长度。参与自愿运动的动物表现出神经发生增加，并且所有颗粒细胞区中具有一两个初级树突的细胞比例均增加。尽管初级过程较少，但这些细胞表现出增强的树突复杂性和总树突长度的总体增加。这些结果表明，颗粒细胞树突形态可能表明颗粒细胞层中细胞的年龄和位置，但在神经发生率增加的动物中，在齿状回细胞层的所有区域中表现出不成熟表型的细胞比例增加。 (c) 2005 年由 Elsevier Ltd 代表 IBRO 出版。
Neurogenesis is a constitutive activity in the adult dentate gyrus whereby new cells are created in the subgranular zone, before becoming neurons in the dentate gyrus granule cell layer. New granule cells are thought to migrate from the subgranular zone outwards to the edge of the cell layer as they mature. In these experiments we examined the dendritic morphology of granule cells in the subgranular zone, and the inner and outer regions of the granule cell zone in Sprague-Dawley rats with low and high rates of neurogenesis. In animals with lower rates of neurogenesis, the number of primary dendrites, degree of dendritic complexity and total dendritic length was lowest in cells located in the subgranular zone, higher in inner granule cell zone neurons, and highest in outer granule cell zone granule cells. Subgranular zone granule cells typically extended one primary dendrite and had a simple, immature dendritic tree, while granule cells in the outer granule cell zone had an increased number of primary dendrites, greater dendritic complexity, and greater total dendritic length. Animals that engaged in voluntary exercise showed increased neurogenesis, and the proportion of cells with one or two primary dendrites was increased in all of the granule cell zones. Despite having fewer primary processes, these cells showed enhanced dendritic complexity and an overall increase in their total dendritic length. These results indicate that granule cell dendritic morphology may be indicative of the age and position of a cell in the granule cell layer, but that in animals with increased rates of neurogenesis, the proportion of cells exhibiting what is considered an immature phenotype is increased throughout the all regions of the dentate gyrus cell layer. (c) 2005 Published by Elsevier Ltd on behalf of IBRO.