Dynamic Introduction of Cell Adhesive Factor via Reversible Multicovalent Phenylboronic Acid/cis-Diol Polymeric Complexes
Dynamic Introduction of Cell Adhesive Factor via Reversible Multicovalent Phenylboronic Acid/cis-Diol Polymeric Complexes
复制标题
通过可逆多共价苯基硼酸/顺式二醇聚合物复合物动态引入细胞粘附因子
DOI：
10.1021/ja501664f
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发表时间：
2014-04-30
影响因子：
15
通讯作者：
Shea, Kenneth J.
中科院分区：
文献类型：
--
作者：
Pan, Guoqing;Guo, Bingbing;Shea, Kenneth J.
在这项工作中，动态引入生物活性的RGD肽的基质上成功地证明了通过可逆的多共价相互作用PBA/顺式二醇聚合物复合物。这些可逆的、稳定的多重相互作用位点，除了长的可接近的聚合物接头之外，使得能够通过特异性生物分子交换（例如，葡萄糖或果糖）。这种生物分子触发的非侵入性策略在实时生物研究中显示出巨大的前景，并模仿天然生物分子反馈系统，从而在医学诊断和再生医学中具有潜在的应用。
In this work, dynamic introduction of bioactive RGD peptide on a matrix was successfully demonstrated via reversible multicovalent interactions within PBA/cis-diol polymeric complexes. These reversible, stable multiple interaction sites, in addition to a long accessible polymeric linker, enabled "reversible" control of cell adhesion by specific biomolecular exchange (e.g., glucose or fructose). This biomolecule-triggered, non-invasive strategy shows great promise for use in real-time biological research and mimics natural biomolecular feedback systems, thus having potential application in medical diagnoses and regenerative medicine.