White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study
White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study
复制标题
帕金森病抑郁症丘脑白质微结构变化：弥散张量磁共振成像研究
DOI：
10.3174/ajnr.a2195
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发表时间：
2010-11-01
影响因子：
3.5
通讯作者：
Li, K.
中科院分区：
文献类型：
--
作者：
Li, W.;Liu, J.;Li, K.
背景与目的：抑郁是帕金森病的常见症状，但其神经基础尚不清楚。本研究的目的是表征可能与抑郁相关的白色物质的微结构变化与DPD患者的丘脑与NDPD相比。材料与方法：对14例DPD和18例NDPD患者进行DTI FA和MD成像。在FA图上进行感兴趣区域引导的MRI，以检测这两个患者组之间丘脑中可能的显微结构差异。此外，平均FA和MD的区域检测到的差异进行了比较DPD和NDPD组之间，扩散量和抑郁症的严重程度之间的相关性进行了分析。结果：DPD与NDPD患者双侧丘脑背内侧区的白色物质显微结构存在差异。在这些地区，DPD患者的FA值显著低于NDPD患者（P <0.005），PD患者的FA均值与抑郁严重程度评分呈负相关（P <0.05）。两组间丘脑背内侧区MD无显著性差异。结论：我们的研究结果提供了初步的证据，内侧背丘脑可能在PD抑郁症中发挥重要作用，并建议FA在内侧背丘脑和DPD患者的抑郁症状的存在之间的关系。这些发现可能有助于进一步了解PD抑郁的潜在机制。
BACKGROUND AND PURPOSE: Depression occurs frequently in PD; however the neural basis of depression in PD remains unclear. The aim of this study was to characterize possible depression-related white matter microstructural changes in the thalamus of patients with DPD compared with those with NDPD. MATERIALS AND METHODS: FA and MD maps from DTI were obtained in 14 patients with DPD and 18 patients with NDPD. Region-of-interest−guided VBA was conducted on the FA maps to detect possible microstructural differences in the thalamus between these 2 patient groups. Moreover, mean FA and MD in regions with a detected difference were compared between DPD and NDPD groups, and correlations between diffusion quantities and the severity of depression were analyzed. RESULTS: White matter microstructure differences were found between the patients with DPD and NDPD in the bilateral mediodorsal thalamic regions. In these regions, patients with DPD showed significantly decreased FA values (P < .005) compared with patients with NDPD, and the mean values of FA were negatively correlated with the scores of depression severity (P < .05) for patients with PD. No significant differences of MD were found in the mediodorsal thalamus between these 2 groups. CONCLUSIONS: Our results provide preliminary evidence that the mediodorsal thalamus may play an important role in depression in PD and suggest a relationship between FA in the mediodorsal thalamus and the presence of depressive symptoms in patients with DPD. These findings may be helpful for further understanding the potential mechanisms of depression in PD.