Bad blood: the risks of red cell storage.
Bad blood: the risks of red cell storage.
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DOI：
10.1038/nm0410-381
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发表时间：
2010-04
期刊：
影响因子：
82.9
通讯作者：
Gladwin MT
中科院分区：
文献类型：
--
作者：
Lee JS;Gladwin MT
输血挽救了许多生命，但也带来了受伤的风险，比如对肺部的严重损伤。在《从床边到长凳》一书中，珍妮特·s·李和马克·t·格拉德温研究了评估这种损害的临床研究的意义。受伤的风险似乎随着输血单位的增加而增加，并且随着血液储存时间的延长而增加。研究人员还没有弄清楚其中的原因，但有几种机制正在研究中。在“从实验室到病床”中，Paul S. Frenette和Narla Mohandas讨论了最近的研究，指出了一种触发因素——中性粒细胞上的一种特异性抗原，用于治疗严重形式的输血相关急性肺损伤（TRALI）。这一发现可能会带来诊断TRALI和识别高危人群的新方法。
Blood transfusion saves many lives but carries the risk of injury, such as severe damage to the lungs. In 'Bedside to Bench', Janet S. Lee and Mark T. Gladwin examine the implications of clinical studies assessing such damage. The risk of injury seems to increase with the number of units transfused and may be greater with blood that has been stored longer. Researchers have yet to understand why, but several mechanisms are under scrutiny. In 'Bench to Bedside', Paul S. Frenette and Narla Mohandas discuss recent studies pinpointing a trigger—a specific antigen on neutrophils for a severe form of transfusion-related acute lung injury (TRALI). The findings could lead to new ways to diagnose TRALI and identify people at risk.