UPLC-Q-TOF-MS/MS fingerprinting of Traditional Chinese Formula SiJunZiTang
UPLC-Q-TOF-MS/MS fingerprinting of Traditional Chinese Formula SiJunZiTang
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DOI：
10.1016/j.jpba.2013.02.021
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发表时间：
2013-06-01
影响因子：
3.4
通讯作者：
Zhang, Qinglin
中科院分区：
文献类型：
--
作者：
Wang, Yanyan;He, Shan;Zhang, Qinglin
四君子汤是由人参、白术、茯苓、甘草四味药组成的经典中药方剂，具有保护胃肠功能的作用。需要色谱质量控制。UPLC-Q-TOF-MS是一种与UPLC和串联质谱（MS/MS）相结合的快速有效的复杂样品分析技术。本文建立了SJZT的UPLC-MS指纹图谱。结果表明，共检测到66个化合物，包括皂苷类、黄酮类、三萜类和香豆素类，其中58个化合物已初步鉴定。人参总皂苷的主要成分为人参皂苷和甘草黄酮。(C)2013爱思唯尔有限公司版权所有。
SiJunZiTang (SJZT), a classic Traditional Chinese Formula (TCMF) consisting of four herbs, Radix Ginseng, Atractylodes macrocephala, Poria cocos and Glycyrrhiza uralensis, has been demonstrated to show protective effects on intestine and stomach injure. The chromatographic quality control is needed. UPLC-Q-TOF-MS is a rapid and efficient technique for analysis of complex sample in combination with UPLC and tandem mass spectrometry (MS/MS). In this paper, UPLC-MS fingerprinting of SJZT was developed. As a result, 66 compounds including ginsenosides, flavonoids, triterpenoid and coumarins were detected, 58 of them were tentatively identified. The major constituents of SJZT were ginsenosides and flavonoids that coming from Radix Ginseng and Glycyrrhiza uralensis. (C) 2013 Elsevier B.V. All rights reserved.