Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient.
Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient.
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DOI：
10.6133/apjcn.2008.17.s1.47
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发表时间：
2008
影响因子：
1.3
通讯作者：
Hayato Maeda;Takayuki Tsukui;Tokutake Sashima;M. Hosokawa;K. Miyashita
中科院分区：
文献类型：
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作者：
Hayato Maeda;Takayuki Tsukui;Tokutake Sashima;M. Hosokawa;K. Miyashita
岩藻黄素具有独特的结构，包括一个不寻常的异位键和分子中的5,6 -单环氧化物。我们发现，饲喂岩藻黄素的大鼠和小鼠腹部白色脂肪组织（WAT）重量显著低于饲喂对照饲料的大鼠和小鼠。老鼠每天摄入岩藻黄素也能显著减轻体重。在饲喂岩藻黄素的小鼠腹腔WAT中，Western和Northern blot检测到解偶联蛋白1 （uncoupling protein 1, UCP1）及其mRNA的清晰信号，而饲喂对照饮食的小鼠腹腔WAT中UCP1的表达很少。摄入岩藻黄素导致WAT中UCP1的表达导致WAT线粒体中脂肪酸氧化和产热。底物氧化可直接降低动物的WAT。岩藻黄素的摄入也显著降低了血糖和血浆胰岛素。此外，饲喂岩藻黄素显著提高了肝脏二十二碳六烯酸（DHA）水平，DHA是生物系统中最重要的n-3功能多不饱和脂肪酸。岩藻黄素的这些多功能表明它是一种重要的生物活性类胡萝卜素，有利于预防代谢综合征。
Fucoxanthin has a unique structure including an unusual allenic bond and 5, 6-monoepoxide in its molecule. We found that abdominal white adipose tissue (WAT) weights of rats and mice fed fucoxanthin were significantly lower than those fed a control diet. The daily intake of fucoxanthin in mice also caused a significant reductions of body weight. Clear signals of uncoupling protein 1 (UCP1) and its mRNA were detected by Western and Northern blot analyses in abdominal WAT in mice fed fucoxanthin, although there is little expression of UCP1 in WAT in mice fed a control diet. UCP1 expression in WAT by fucoxanthin intake leads to oxidation of fatty acids and heat production in WAT mitochondria. Substrate oxidation can directly reduce WAT in animals. Fucoxanthin intake also significantly reduced blood glucose and plasma insulin. Furthermore, feeding fucoxanthin significantly increased the level of hepatic docosahexaenoic acid (DHA), a most important n-3 functional polyunsaturated fatty acid in biological systems. These multi-functionalities of fucoxanthin indicate that it is an important bioactive carotenoid that is beneficial for the prevention of the metabolicsyndrome.