Role of infections in the induction and development of asthma: genetic and inflammatory drivers.
Role of infections in the induction and development of asthma: genetic and inflammatory drivers.
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DOI：
10.1586/1744666x.5.1.97
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发表时间：
2009-01-01
影响因子：
4.4
通讯作者：
Chu HW
中科院分区：
文献类型：
--
作者：
Wu Q;Chu HW
遗传和环境因素相互作用，启动甚至维持哮喘的进程。作为高风险的环境因素之一，易感个体的感染可促进哮喘的发展和加重和/或延长症状。本综述将描述我们目前对先天免疫的遗传标记在哮喘的诱导和发展中的理解，感染在调节过敏性炎症中的不同作用，宿主对感染的易感性以及过敏性环境中随后的急性加重，以及现有知识的治疗或预防意义。最后讨论了哮喘基础和临床研究面临的挑战和未来的发展方向。
Genetic and environmental factors interact to initiate and even maintain the course of asthma. As one of the highly risky environmental factors, infections in predisposed individuals can promote asthma development and exacerbations and/or prolong symptoms. This review will describe our current understanding of the genetic markers of innate immunity in the induction and development of asthma, the diverse roles of infections in modulating allergic inflammation, host susceptibility to infections and subsequent acute exacerbations in an allergic setting, and the therapeutic or preventive implications of existing knowledge. Current challenges and future directions in basic and clinical research of asthma are also discussed.