BREAST-CANCER RECURRENCE AFTER LUMPECTOMY AND RADIATION-THERAPY FOR EARLY-STAGE DISEASE - PROGNOSTIC-SIGNIFICANCE OF DETECTION METHOD
BREAST-CANCER RECURRENCE AFTER LUMPECTOMY AND RADIATION-THERAPY FOR EARLY-STAGE DISEASE - PROGNOSTIC-SIGNIFICANCE OF DETECTION METHOD
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DOI：
10.1148/radiology.188.1.8511295
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发表时间：
1993-07-01
期刊：
影响因子：
19.7
通讯作者：
TROUPIN, RH
中科院分区：
文献类型：
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作者：
GREENSTEIN, S;FOWBLE, BL;TROUPIN, RH
评估了肿瘤切除和放射治疗后局部复发检测模式的预后意义。美国癌症联合委员会 I 期和 II 期浸润性乳腺癌接受肿瘤切除术和放射治疗的 72 名女性同侧乳房出现复发性癌症，在复发时进行了体格检查和乳房 X 光检查，并接受了挽救性乳房切除术。单独使用乳房X光检查检测与较低T分期之间存在统计学上显着的关联（P = .05），并且存在非侵入性组织学发现的非统计学显着趋势。检测方法与乳腺癌复发部位、复发间隔或患者年龄之间没有显着关联。仅通过乳房X光检查检测到复发的患者存在无统计学意义的显着趋势，即改善无复发生存期和总生存期。这些结果表明，放射后监测乳房X线照相术对于早期发现复发性癌症很重要。虽然这一趋势并未达到统计学显着性，但仅通过乳房X线摄影检测对无复发生存率和总生存率具有临床上明显的影响。
The prognostic implications of detection mode in local recurrence after lumpectomy and radiation therapy were assessed. Seventy-two women treated with lumpectomy and irradiation for American Joint Committee on Cancer stages I and II invasive breast cancer developed recurrent cancer in the ipsilateral breast, had physical examination and mammography performed at the time of recurrence, and underwent salvage mastectomy. There was a statistically significant association between detection with mammography alone and lower T stage (P = .05), and there was a nonstatistically significant trend toward noninvasive histologic findings. No significant association was noted between detection method and site of recurrent cancer in the breast, interval to recurrence, or patient age. There were nonstatistically significant trends toward improved relapse-free survival and overall survival for patients with recurrences detected solely with mammography. These results demonstrate that postirradiation surveillance mammography is important for the early detection of recurrent cancer. While the trend did not reach statistical significance, detection with mammography alone had a clinically apparent impact on relapse-free and overall survival.