Classical swine fever virus strain 'C'. How long is it detectable after oral vaccination?
Classical swine fever virus strain 'C'. How long is it detectable after oral vaccination?
复制标题
DOI：
10.1111/j.1439-0450.2004.00766.x
复制
发表时间：
2004-08-01
期刊：
影响因子：
--
通讯作者：
Lange, B
中科院分区：
文献类型：
--
作者：
Kaden, V;Lange, E;Lange, B
为确定C株疫苗病毒在免疫动物体内的存留期，对家猪和野猪进行口服免疫，并于免疫后不同天数（dpv）处死。尸检时从两个种属中采集组织样本，用于检测C株病毒。还采集了家猪的鼻拭子和粪便。在研究期间（2-12 dpv），在接种家猪的鼻分泌物和粪便中从未检出疫苗病毒。相比之下，C-株病毒被发现在器官中，直到第8天PV的家猪和直到第9天PV的野猪。而在家猪扁桃体中检测到病毒，Ln。在野猪中仅在扁桃体中发现。我们的结论是，C-株疫苗病毒是检测不到野猪超过10-12天后摄入的疫苗诱饵。
To determine the persistence period of C-strain vaccine virus in immunized animals, domestic pigs and wild boars were vaccinated orally and killed on different days post vaccinationem (dpv). Tissue samples were taken at necropsy from both species for detection of C-strain virus. From domestic pigs nasal swabs and faeces were also collected. During the investigation period (2-12 dpv) vaccine virus could never be detected in nasal secretions and in faeces of vaccinated domestic pigs. In contrast, C-strain virus was found in organs until day 8 pv in domestic pigs and until day 9 pv in wild boars. Whereas in domestic pigs virus was detected in tonsils, Ln. mandibularis or in spleen, in wild boar it only was found in tonsils. We conclude that C-strain vaccine virus is not detectable in wild boars longer than 10-12 days after intake of the vaccine baits.