Diagnostic significance of interferon-γ in tuberculous pleural effusions
Diagnostic significance of interferon-γ in tuberculous pleural effusions
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DOI：
10.1378/chest.123.3.740
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发表时间：
2003-03-01
期刊：
影响因子：
9.6
通讯作者：
Takeyama, H
中科院分区：
文献类型：
--
作者：
Aoe, K;Hiraki, A;Takeyama, H
研究目的：结核病（TB）是世界范围内最常见的单一感染性死亡原因，也是胸腔积液的主要原因，其在TB中通常具有淋巴细胞和渗出性特征。结核病和非结核性胸腔积液之间的鉴别诊断有时是困难的，代表一个非常重要的临床problems.Methods：我们研究了46例胸腔积液的国立三洋医院2000年4月至2001年1月（34名男性和12名女性，平均年龄64岁）。10名患者（22%）患有结核性胸膜炎，19名患者（41%）患有恶性胸膜炎，17名患者（37%）因结核或癌症以外的病因而发生胸腔积液。结果：胸水腺苷脱氨酶水平（平均值± SE）（83.3 ± 18.2 U/L vs 25.8 ± 20.4 U/L，p < 0.01）与胸水腺苷脱氨酶水平（平均值± SE）（平均值± SE）（83.3 ± 18.2 U/L vs 25.8 ± 20.4 U/L，p < 0.01）相比，差异有统计学意义（P < 0.05）。
Study objectives: Tuberculosis (TB), the single most frequent infectious cause of death worldwide, also is a major cause of pleural effusion, which in TB usually has lymphocytic and exudative characteristics. Differential diagnosis between TB and nontuberculous pleural effusion can be sometimes difficult, representing a critically important clinical problem.Methods: We studied 46 patients presenting with pleural effusion to the National Sanyo Hospital between April 2000 and January 2001 (34 men and 12 women; mean age, 64 years). Ten patients (22%) had tuberculous pleurisy, 19 patients (41%) had malignant pleuritis, and 17 patients (37%) had pleural effusion due to an etiology other than tuberculosis or cancer. Pleural fluid concentrations of four suggested markers were measured using commercially available kits.Results: The pleural fluid levels (mean+/-SE) of adenosine deaminase (83.3+/-18.2 U/L vs 25.8+/-20.4 U/L, p