Image Inversion Spectral-Domain Optical Coherence Tomography Optimizes Choroidal Thickness and Detail through Improved Contrast
Image Inversion Spectral-Domain Optical Coherence Tomography Optimizes Choroidal Thickness and Detail through Improved Contrast
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DOI：
10.1167/iovs.11-9290
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发表时间：
2012-04-01
影响因子：
4.4
通讯作者：
Mruthyunjaya, Prithvi
中科院分区：
文献类型：
--
作者：
Lin, Phoebe;Mettu, Priyatham S.;Mruthyunjaya, Prithvi
目的.本研究旨在确定倒置与直立光谱域光学相干断层扫描（SD-OCT）在脉络膜厚度、对比度、脉络膜外血管（OCV）和脉络膜-巩膜连接（CSJ）可视化方面是否存在显著差异。在Bioptigen SD-OCT、Zeiss Cirrus HD-OCT和Heidelberg Spectralis上采集21名健康受试者42只眼睛的图像。用MATLAB确定以中心凹为中心的4 mm段的平均脉络膜厚度。测量脉络膜对比度的定量测量，并通过应用0至3分的评分来评估CSJ。通过计数>= 200 μ m. MTS的脉络膜血管来确定OCV。Bioptigen倒置图像的平均脉络膜厚度大于Bioptigen直立图像的平均脉络膜厚度（P <0.05）。Spectralis倒置模式的平均OCV最高。可视化CSJ和OCV的最有利模式是Spectralis EDI、Spectralis倒置、Cirrus直立和Bioptigen倒置。这些模式展示了最高的外部脉络膜对比度和脉络膜厚度测量。由于转换因子的差异，无法比较不同机器之间的脉络膜厚度。未来的研究和自动分割和检测软件的建设应该考虑到这些好处和陷阱。（Invest Ophthalmol维斯科学。2012;53：1874-1882）DOI：10.1167/iovs.11-9290
PURPOSE. This study was conducted to determine whether there were significant differences in choroidal thickness, contrast, outer choroidal vessel (OCV), and choroidal-scleral junction (CSJ) visualization in inverted versus upright spectral-domain optical coherence tomography (SD-OCT).METHODS. Images were captured on Bioptigen SD-OCT, Zeiss Cirrus HD-OCT, and Heidelberg Spectralis in 42 eyes of 21 healthy subjects. Average choroidal thickness across a fovea-centered 4-mm segment was determined with MATLAB. Quantitative measures of choroidal contrast were measured and CSJ assessed by applying a score of 0 to 3. OCV was determined by counting choroidal vessels >= 200 mu m.RESULTS. Mean choroidal thickness was greater in inverted versus upright images captured by Bioptigen (P Bioptigen inverted. Mean OCV was highest in Spectralis inverted mode.CONCLUSION. The most favorable modes to visualize CSJ and OCV are the Spectralis EDI, Spectralis inverted, Cirrus upright, and Bioptigen inverted. These modes demonstrate the highest outer choroidal contrast and choroidal thickness measurements. Choroidal thickness cannot be compared between machines due to conversion factor differences. Future studies and construction of automated segmentation and detection software should take these benefits and pitfalls into account. (Invest Ophthalmol Vis Sci. 2012;53:1874-1882) DOI:10.1167/iovs.11-9290