Global estimates on the number of persons across the Alzheimer's disease continuum
Global estimates on the number of persons across the Alzheimer's disease continuum
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DOI：
10.1002/alz.12694
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发表时间：
2022-06-02
影响因子：
14
通讯作者：
van der Flier, Wiesje M.
中科院分区：
文献类型：
--
作者：
Gustavsson, Anders;Norton, Nicholas;van der Flier, Wiesje M.
目前缺乏对阿尔茨海默病（AD）早期（包括前驱期和临床前）患者人数的全球估计，但需要为有关预防措施和针对AD病理的未来治疗计划的政策决策提供信息。方法：我们综合了AD连续体患病率的文献，并推导出一个模型，估计人数，分层5岁年龄组，性别和疾病阶段（AD痴呆，前驱AD和临床前AD）。结果全球AD痴呆、前驱AD和临床前AD患者的数量分别估计为3200万、6900万和3.15亿。他们在整个AD连续统中共占4.16亿人，占所有50岁及以上人口的22%。讨论考虑到痴呆前期阶段，AD患者的数量远远大于现有文献中所传达的。我们的估计是不确定的，特别是对于低收入和中等收入地区的痴呆前期阶段，那里缺少生物标志物研究。
Introduction Global estimates on numbers of persons in early stages of Alzheimer's disease (AD), including prodromal and preclinical, are lacking, yet are needed to inform policy decisions on preventive measures and planning for future therapies targeting AD pathology. Methods We synthesized the literature on prevalence across the AD continuum and derived a model estimating the number of persons, stratified by 5-year age groups, sex, and disease stage (AD dementia, prodromal AD, and preclinical AD). Results The global number of persons with AD dementia, prodromal AD, and preclinical AD were estimated at 32, 69, and 315 million, respectively. Together they constituted 416 million across the AD continuum, or 22% of all persons aged 50 and above. Discussion Considering predementia stages, the number of persons with AD is much larger than conveyed in available literature. Our estimates are uncertain, especially for predementia stages in low- and middle-income regions where biomarker studies are missing.