Microvascular Complications of Diabetes Mellitus: Renal Protection Accompanies Cardiovascular Protection
Microvascular Complications of Diabetes Mellitus: Renal Protection Accompanies Cardiovascular Protection
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DOI：
10.1016/j.amjcard.2008.09.068
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发表时间：
2008-12-22
影响因子：
2.8
通讯作者：
Brown, W. Virgil
中科院分区：
文献类型：
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作者：
Brown, W. Virgil
糖尿病的微血管并发症会导致大量的发病率，并损害患者的生活质量。血脂异常和长期高血糖促进氧化应激、炎症和血管损伤的增加，这些共同促进内皮功能障碍，并与大血管和微血管并发症相关。微量白蛋白尿是糖尿病肾病的早期标志物，也是心血管疾病的独立危险因素。糖尿病肾病是发达国家终末期肾病最常见的原因，其患病率正在增加。预防或限制糖尿病肾病的进展，如非诺贝特干预和降低糖尿病事件（FIELD）试验所示，可以预防或延迟肾脏并发症，并在2型糖尿病患者中传达重要的心脏保护益处。(c)爱思唯尔公司出版(Am J Cardiol 2008; 102 [增刊]：10 L-13 L）
The microvascular complications of diabetes mellitus confer substantial morbidity and impair patient quality of life. Dyslipidemia and prolonged hyperglycemia promote an increase in oxidative stress, inflammation, and vascular damage, which together promote endothelial dysfunction and are associated with macrovascular and microvascular complications. Microalbuminuria is an early marker of diabetic nephropathy and an independent risk factor for cardiovascular disease. Diabetic nephropathy is the most common cause of end-stage renal disease in developed countries, and its prevalence is increasing. Preventing or limiting the progression of diabetic nephropathy, as demonstrated in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial, may prevent or delay renal complications, as well as convey important cardioprotective benefits in patients with type 2 diabetes. (c) Published by Elsevier Inc. (Am J Cardiol 2008;102[suppl]:10L-13L)