Design of templated nanoporous carbon electrode materials with substantial high specific surface area for simultaneous determination of biomolecules.
Design of templated nanoporous carbon electrode materials with substantial high specific surface area for simultaneous determination of biomolecules.
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DOI：
10.1016/j.bios.2012.10.043
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发表时间：
2013-04
影响因子：
12.6
通讯作者：
Shenghai Zhou;Hongyan Shi;Xun Feng;Kaiwen Xue;Wenbo Song
中科院分区：
文献类型：
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作者：
Shenghai Zhou;Hongyan Shi;Xun Feng;Kaiwen Xue;Wenbo Song
纳米多孔碳材料在电催化和生物传感器的电极设计方面引起了人们的极大兴趣。本文以介孔硅酸盐为模板剂，酸为催化剂，采用纳米铸造法，设计并合成了三种不同比表面积的模板化纳米多孔碳材料。然后以TNCs为电极材料，在生理pH条件下同时测定多巴胺(DA)、抗坏血酸(AA)和尿酸(UA)。研究了跨国公司的比表面积、边平面缺陷部位与其对AA、DA和UA的区分能力之间的相关性。对于比表面积较大、缺陷位较多的跨国公司，AA、DA和UA的氧化峰被很好地分离，氧化电流显著增加。通过设计具有最大比表面积和最多缺陷位置的TNCS1作为电极材料，实现了同时检测这些生物分子的高灵敏度电化学传感器。AA、DA和UA在传感器上的灵敏度分别为0.012、4.031、0.605μA/μM。结果表明，TNCs1在生物大分子的同时检测中具有广阔的应用前景。这项工作对寻找用于生物传感和电催化的优秀碳材料的科学家也可能有价值。
Nanoporous carbon materials have attracted significant interests in the design of electrodes for electrocatalysis and biosensors. Here, three templated nanoporous carbons (TNCs) materials with substantial different specific surface area were designed and synthesized by a nanocasting method, in which mesoporous silicates and acid were used as template and catalyst, respectively. The TNCs were then used as electrode materials for simultaneous detection of dopamine (DA), ascorbic acid (AA) and uric acid (UA) at physiological pH. The correlations between specific surface area, edge-plane defect sites in TNCs and their distinguishing ability towards AA, DA, and UA were investigated. For TNCs with substantial larger specific surface area and more defect sites, the oxidation peaks of AA, DA and UA were separated well and their oxidation currents increased remarkably. A highly sensitive electrochemical sensor for simultaneous detection of those biomolecules was achieved by designing TNCs1 with the largest specific surface area and the most defect sites as the electrode material. The sensitivity of AA, DA and UA at the sensor is 0.012, 4.031, 0.605μA/μM respectively. Results suggest that TNCs1 is promising in biomolecules simultaneous detection. This work may also be valuable for scientists who search for excellent carbon materials for biosensing and electrocatalysis.