Sodium-lithium countertransport and probability of hypertension in Caucasians 47 to 89 years old.
Sodium-lithium countertransport and probability of hypertension in Caucasians 47 to 89 years old.
复制标题
47 至 89 岁白种人的钠-锂逆转运和高血压概率。
DOI：
10.1161/01.hyp.20.6.841
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Sing,CF
中科院分区：
文献类型：
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作者：
Turner,ST;Rebbeck,TR;Sing,CF
本研究的目的是确定钠-锂逆向转运是否有助于预测患高血压的可能性，并在考虑其他预测特征后确定其是否有助于预测。我们使用逻辑回归来模拟钠-锂反转运与患高血压的概率之间的关系，通过明尼苏达州罗切斯特市白人群体中 172 名男性和 252 名年龄在 47-89 岁的女性中的高血压患病率来估计。当钠-锂反转运是考虑的唯一预测性状时，它对男性的预测做出了统计上显着的贡献（模型 chi(2)1df = 20.50，p < 0.001）和女性（模型 chi(2)1df = 16.69，p < 0.001）。钠-锂逆向转运的标准差每增加一个，男性患高血压的预期几率就会增加 2.25 倍（95% 置信区间 [CI]，1.44-3.51），女性患高血压的几率增加 1.77 倍（95% CI，1.32-2.37）。当不考虑钠-锂反转运时，被确定为预测因素的其他特征是年龄、体重指数、血浆载脂蛋白 CII 和 CII 平方；血浆载脂蛋白 AI 是女性的另一个预测因子，但对男性则不然。当将钠-锂反向转运添加到包含其他预测因子的模型中时，它改善了男性（模型 chi(2)1df = 12.29 增加，p < 0.001）和女性（模型 chi(2)1df = 4.86 增加，p < 0.027）的预测。基于这些完整的模型，当其他预测因子保持在平均值时，钠-锂逆向转运的标准差每增加一个，男性患高血压的预期几率就会增加 2.06 倍（95% CI，1.31-3.22），女性患高血压的几率增加 1.48 倍（95% CI，1.04-2.21）。这些结果表明，钠-锂逆向转运提供的信息有助于预测患有高血压的可能性，并且未反映在其他已确定的预测性状中。
The objectives of the present study were to determine whether sodium-lithium countertransport contributes to predicting the probability of having hypertension and to determine whether it does so after other predictor traits have been considered. We used logistic regression to model the relation between sodium-lithium countertransport and the probability of having hypertension, estimated by the prevalence of hypertension among 172 men and 252 women, aged 47-89 years, from the Caucasian population of Rochester, Minn. When sodium-lithium countertransport was the only predictor trait considered, it made a statistically significant contribution to prediction both in men (model chi(2)1df = 20.50, p < 0.001) and in women (model chi(2)1df = 16.69, p < 0.001). For each standard deviation increase in sodium-lithium counter-transport, the expected odds of having hypertension increased 2.25 times in men (95% confidence interval [CI], 1.44-3.51) and 1.77 times in women (95% CI, 1.32-2.37). When sodium-lithium countertransport was not considered, the other traits identified as predictors were age, body mass index, and plasma apolipoprotein CII and CII squared; plasma apolipoprotein AI was an additional predictor in women but not in men. When sodium-lithium countertransport was added to models that included the other predictors, it improved prediction both in men (increase in model chi(2)1df = 12.29, p < 0.001) and in women (increase in model chi(2)1df = 4.86, p < 0.027). Based on these complete models, when the other predictors remained at their mean values, each standard deviation increase in sodium-lithium countertransport increased the expected odds of having hypertension 2.06 times in men (95% CI, 1.31-3.22) and 1.48 times in women (95% CI, 1.04-2.21). These results establish that sodium-lithium countertransport provides information that is helpful in predicting the probability of having hypertension and is not reflected in other identified predictor traits.