Molecular Basis of Exercise-Induced Skeletal Muscle Mitochondrial Biogenesis: Historical Advances, Current Knowledge, and Future Challenges
Molecular Basis of Exercise-Induced Skeletal Muscle Mitochondrial Biogenesis: Historical Advances, Current Knowledge, and Future Challenges
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DOI：
10.1101/cshperspect.a029686
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发表时间：
2018-09-01
影响因子：
5.4
通讯作者：
Hawley, John A.
中科院分区：
文献类型：
--
作者：
Perry, Christopher G. R.;Hawley, John A.
我们提供了一个突破性的研究，为我们目前的运动诱导的线粒体生物合成及其对人类骨骼肌健身的贡献的理解奠定了基础的概述。我们强调的机制，骨骼肌响应细胞能量稳态的急性扰动引起的单回合的耐力为基础的运动和适应运动训练，最终通过激素反馈回路促进线粒体生物合成的重复需求。尽管密集的研究努力，以阐明支持骨骼肌线粒体生物发生的细胞机制，将这一基础知识转化为改善代谢健康的人口水平仍然是未来的挑战。
We provide an overview of groundbreaking studies that laid the foundation for our current understanding of exercise-induced mitochondrial biogenesis and its contribution to human skeletal muscle fitness. We highlight the mechanisms by which skeletal muscle responds to the acute perturbations in cellular energy homeostasis evoked by a single bout of endurance-based exercise and the adaptations resulting from the repeated demands of exercise training that ultimately promote mitochondrial biogenesis through hormetic feedback loops. Despite intense research efforts to elucidate the cellular mechanisms underpinning mitochondrial biogenesis in skeletal muscle, translating this basic knowledge into improved metabolic health at the population level remains a future challenge.