Chromosomal mapping of TMP (EMP1), XMP (EMP2), and YMP (EMP3), genes encoding membrane proteins related to PMP22
Chromosomal mapping of TMP (EMP1), XMP (EMP2), and YMP (EMP3), genes encoding membrane proteins related to PMP22
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DOI：
10.1006/geno.1998.5238
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发表时间：
1998-05-01
期刊：
影响因子：
4.4
通讯作者：
Benvenisty, N
中科院分区：
文献类型：
--
作者：
Ben-Porath, I;Kozak, CA;Benvenisty, N
我们最近发现了一个新的哺乳动物基因家族，编码具有四个跨膜结构域的膜糖蛋白。该基因家族包括先前研究的参与Charcot-Marie-Tooth神经病的PMP 22和三个新基因：TMP，XMP和YMP（分别为HGMW批准的符号EMP 1，EMP 2和EMP 3）。Tmp（肿瘤相关膜蛋白）基因分离自c-myc诱导的小鼠脑肿瘤，并在几种高度增殖的细胞类型中表达。我们现在已经分离出小鼠Xmp和Ymp基因的cDNA，并确定了小鼠Tmp、Xmp和Ymp的染色体定位。TMP定位于小鼠6号染色体，Xmp定位于16号染色体，Ymp定位于7号染色体。TMP和Ymp映射到旁系同源染色体区域，而Xmp映射到与11号染色体上的区域（Pmp 22先前映射到该区域）旁系同源的染色体区域。这些数据表明，这个膜糖蛋白家族是染色体复制的结果，（C）1998年学术出版社。
We have recently characterized a novel mammalian gene family, encoding membrane glycoproteins with four trans-membrane domains. This gene family includes the previously studied PMP22, which is involved in the Charcot-Marie-Tooth neuropathy, and three novel genes: TMP, XMP, and YMP (HGMW-approved symbols EMP1, EMP2 and EMP3, respectively). The Tmp (tumor-associated membrane protein) gene was isolated from a c-myc induced mouse brain tumor and is expressed in several highly proliferative cell types. We have now isolated cDNAs of the mouse Xmp and Ymp genes and determined the chromosomal localization of mouse Tmp, Xmp, and Ymp. Tmp was mapped to mouse chromosome 6, Xmp was mapped to chromosome 16, and Ymp was mapped to chromosome 7. Tmp and Ymp map to paralogous chromosomal regions, whereas Xmp maps to a chromosomal region that is putatively paralogous to a region on chromosome 11, to which Pmp22 was previously mapped. These data suggest that this family of membrane glycoproteins evolved as a result of chromosomal duplications, (C) 1998 Academic Press.