Epicardial adipose tissue thickness by echocardiography is a marker for the presence and severity of coronary artery disease
Epicardial adipose tissue thickness by echocardiography is a marker for the presence and severity of coronary artery disease
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DOI：
10.1016/j.numecd.2008.05.002
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发表时间：
2009-03-01
影响因子：
3.9
通讯作者：
Muderrisoglu, H.
中科院分区：
文献类型：
--
作者：
Eroglu, S.;Sade, L. E.;Muderrisoglu, H.
背景和目的：心外膜。脂肪组织（EAT），它被认为是内脏组织的一个组成部分。肥胖与代谢综合征有关。我们的目的是验证超声心动图EAT厚度可以作为冠状动脉疾病（CAD）存在和严重程度的标志的假设。方法和结果：共纳入150例患者（100例CAD患者和50例冠状动脉造影诊断正常患者，女性65例，男性85例，平均年龄55.7±7.4岁）。使用胸骨旁二维超声心动图测量EAT厚度。长轴和短轴视图。将EAT厚度测量值与血管造影结果进行比较。冠心病患者的EAT厚度明显高于正常患者。冠状动脉（6.9 +/- 1.5 mm vs 4.4 +/- 0.8 mm; P < 0.001）。此外，EAT厚度随冠心病严重程度的增加而增加（多血管病变7.4 +/- 1.2 mm vs单血管病变5.7 +/- 1.7 mm; P < 0.001）。Gensini评分与EAT厚度显著相关（r = 0.600, P < 0.001）。>= 5.2 mm的EAT厚度预测CAD的敏感性为85%，特异性为81% （ROC area 0.914, P < 0.001, 95% Cl[0.86-0.96]）。结论：经胸超声心动图可方便、无创地评价EAT厚度，可作为预测冠心病经典危险因素的辅助指标。(C) 2008 Elsevier B.V.版权所有
Background and aim: Epicardial. adipose tissue (EAT), which is thought to be a component of visceral. adiposity, is associated with the metabolic syndrome. We aimed to test the hypothesis that echocardiographic EAT thickness can be a marker for the presence and severity of coronary artery disease (CAD).Method and results: In all, 150 patients (100 patients with CAD and 50 patients with normal coronary arteries by diagnostic coronary angiography; 65 women, 85 men; mean age 55.7 +/- 7.4 years) were enrolled. EAT thickness was measured using 2-D echocardiographic parasternal. long- and short-axis views. EAT thickness measurements were compared with angiographic findings.EAT thickness was significantly higher in patients with CAD in comparison to those with normal. coronary arteries (6.9 +/- 1.5 mm vs. 4.4 +/- 0.8 mm; P < 0.001). Furthermore, EAT thickness increased with the severity of CAD (multivessel disease 7.4 +/- 1.2 mm vs. single vessel disease 5.7 +/- 1.7 mm; P < 0.001). Gensini's score significantly correlated with EAT thickness (r = 0.600, P < 0.001). EAT thickness of >= 5.2 mm had 85% sensitivity and 81% specificity (ROC area 0.914, P < 0.001, 95% Cl [0.86-0.96]) for predicting CAD.Conclusion: EAT thickness, which is easily and non-invasively evaluated by transthoracic echocardiography, can be an adjunctive marker to classical risk factors for the prediction of CAD. (C) 2008 Elsevier B.V. All rights reserved.