Reversible parotid enlargement and pseudo-Sjögren's syndrome secondary to hypertriglyceridemia.

Reversible parotid enlargement and pseudo-Sjögren's syndrome secondary to hypertriglyceridemia.
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可逆性腮腺肿大和继发于高甘油三酯血症的假性干燥综合征。

DOI:
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发表时间:
1996
期刊:
The Journal of rheumatology
影响因子:
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通讯作者:
E. Hess
E. Hess
中科院分区:
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文献类型:
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作者:
J. S. Sheikh;M. Sharma;A. Kunath;D. A. Fritz;C. Glueck;E. Hess

文献摘要

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我们描述了 2 名患有干燥样综合征的患者,该综合征明显继发于高甘油三酯血症。除了肌肉骨骼和干燥症状外,两人还患有双侧腮腺炎。腮腺组织学显示脂肪浸润,无炎症。饮食调整和降甘油三酯药物治疗使一名患者的症状和腮腺肿胀得到缓解。第2名患者的高甘油三酯血症对降甘油三酯药物产生耐药性,腮腺症状和肿胀持续有增无减。我们的研究结果表明,积极治疗假性干燥综合征的高脂血症可能会改善肌肉骨骼和腮腺症状。
We describe 2 patients with a Sjögren-like syndrome apparently secondary to hypertriglyceridemia. Both had bilateral parotitis in addition to musculoskeletal and sicca symptoms. Parotid gland histology revealed fatty infiltration with no inflammation. Therapy with dietary modification and triglyceride lowering drugs resulted in resolution of symptoms and parotid swelling in one patient. In the 2nd patient, hypertriglyceridemia was resistant to triglyceride lowering drugs, and parotid symptoms and swelling continued unabated. Our findings suggest aggressive treatment of hyperlipidemia in pseudo-Sjögren's syndrome may result in amelioration of musculoskeletal and parotid symptoms.