Highly enantioselective phenylacetylene additions to both aliphatic and aromatic aldehydes
Highly enantioselective phenylacetylene additions to both aliphatic and aromatic aldehydes
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DOI：
10.1021/ol026921r
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发表时间：
2002-11-14
期刊：
影响因子：
5.2
通讯作者：
Pu, L
中科院分区：
文献类型：
--
作者：
Gao, G;Moore, D;Pu, L
[图解]在室温下，易于获得且廉价的BINOL与钛((OPR)-Pr-I)(4)相结合，催化炔基锌试剂与各种类型的醛(包括脂肪醛、芳香醛和其他α，β-不饱和醛)反应，生成具有91-99%ee的手性炔丙醇。在此反应中，没有一种手性催化剂对醛的类型表现出如此广泛的对映选择性。
[GRAPHICS]The readily available and inexpensive BINOL in combination with Ti((OPr)-Pr-i)(4) is found to catalyze the reaction of an alkynylzinc reagent with various types of aldehydes including aliphatic aldehydes, aromatic aldehydes, and other alpha,beta-unsaturated aldehydes to generate chiral propargyl alcohols with 91-99% ee at room temperature. No previous chiral catalysts have exhibited such a broad scope of enantioselectivity with respect to the type of aldehydes for this reaction.