Infection with Schistosoma mansoni in mice induces changes in nociception and exploratory behavior
Infection with Schistosoma mansoni in mice induces changes in nociception and exploratory behavior
复制标题
曼氏血吸虫感染小鼠会引起伤害感受和探索行为的变化
DOI：
10.1016/s0031-9384(98)00171-1
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发表时间：
1998
影响因子：
2.9
通讯作者：
L. Aloe
中科院分区：
文献类型：
--
作者：
M. Fiore;E. Alleva;R. Moroni;L. Aloe
Fiore, m ., e. alleva, r. moroni和l. aloe。小鼠感染曼氏血吸虫可引起伤害感受和探索行为的改变。中国生物医学工程学报(2),1998。本研究采用1600条曼氏血吸虫尾蚴经皮感染CD-1小鼠，采用标准化实验（热板、孔板、空地、新物调查、黑白盒）分析小鼠的疼痛敏感性和探索行为。血吸虫感染导致小鼠体重减轻，镇痛作用增强，在孔板试验和黑白试验期间排出的粪便颗粒数量发生变化，在露天场地的运动减少，嗅探、饲养、壁上饲养和探索活动的时间减少。感染还延长了黑/白盒子中从白色隔间到黑色隔间的第一次过渡的潜伏期，焦虑指数增强。目前的研究结果表明，镇痛是血吸虫病的主要影响之一，这表明血吸虫感染引起宿主探索行为和运动活动的不适应反应，与动机和注意力水平的改变有关。此外，尽管小鼠的行为变化似乎与寄生虫/宿主系统中观察到的相似，这些变化应该是对寄生虫的适应性，但在血吸虫/小鼠系统中，宿主行为的变化导致了对寄生虫的不适应性。
FIORE, M., E. ALLEVA, R. MORONI AND L. ALOE. Infection with Schistosoma mansoni in mice induces changes in nociception and exploratory behavior. PHYSIOL BEHAV 65(2) 347–353, 1998.—In this study, CD-1 mice were infected percutaneously with 1600 cercariae of Schistosoma mansoni and their pain sensitivity and exploratory behavior were analyzed in well-standardized tests (hot-plate, hole-board, open-field, novel object investigation and black/white box). Schistosome infection produced body weight reduction, increased analgesia, induced changes in the number of fecal pellets emitted during the hole-board and the black/white tests, induced decreased locomotion in the open-field, decreased sniffing, rearing, wall-rearing and time spent in exploratory activity. The infection also lengthened the latency time to the first transition from the white into the black compartment in the black/white box, index of enhanced anxiety. The present findings indicate that the analgesia is one of the main effects of the disease suggesting that schistosome infection induces maladaptive response in exploratory behavior and in locomotor activity of the host associated with altered motivational and attentional levels. Furthermore, though mouse behavioral changes appear to be similar to those observed in parasite/host systems where the changes are supposed to be adaptive for the parasite, in the case of Schistosoma/mouse system, the changes in host behavior resulted to be not adaptive for the parasite.
实验性鼠血吸虫病细胞因子反应的原位分析。
DOI：
--
发表时间：
1995
期刊：
Laboratory investigation; a journal of technical methods and pathology.
影响因子：
--
作者：
Bogen,SA;FloresVillanueva,PO;McCusker,ME;Fogelman,I;Garifallou,M;el-Attar,ES;Kwan,P;Stadecker,MJ
通讯作者：
Stadecker,MJ
小鼠日本血吸虫病肝纤维化的免疫调节。
DOI：
10.1093/infdis/159.4.798
发表时间：
1989
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Olds,GR;Kresina,TF
通讯作者：
Kresina,TF