Phosphine-catalyzed intramolecular Rauhut-Currier reaction: enantioselective synthesis of hydro-2H-indole derivatives
Phosphine-catalyzed intramolecular Rauhut-Currier reaction: enantioselective synthesis of hydro-2H-indole derivatives
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膦催化分子内Rauhut-Currier反应：氢-2H-吲哚衍生物的对映选择性合成
DOI：
10.1039/c7ob01820g
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发表时间：
2017
影响因子：
3.2
通讯作者：
Huang You
中科院分区：
文献类型：
--
作者：
Jin Hongxing;Zhang Qinglong;Li Erqing;Jia Penghao;Li Ning;Huang You
报道了一种多功能手性氨基膦催化剂催化的高对映选择性分子内Rauhut-Currier反应。以高产率（高达94%）和优良的非对映选择性（高达>20：1 dr和> 99%ee）得到了一系列带有全碳季中心的氢-2H-吲哚衍生物。 并且该反应可以使用2mol%催化剂负载量以克规模进行。
A highly enantioselective intramolecular Rauhut–Currier reaction catalyzed by a multifunctional chiral aminophosphine catalyst was reported. A series of hydro-2H-indole derivatives that bear an all-carbon quaternary center were obtained in high yields (up to 94%), and excellent diastereo- and enantioselectivities (up to >20 : 1 dr and >99% ee). And this reaction could be performed on a gram scale using 2 mol% catalyst loading.