Prenatal exposure to a farm environment modifies atopic sensitization at birth
Prenatal exposure to a farm environment modifies atopic sensitization at birth
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DOI：
10.1016/j.jaci.2008.06.011
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发表时间：
2008-08-01
影响因子：
14.2
通讯作者：
von Mutius, Erika
中科院分区：
文献类型：
--
作者：
Ege, Markus Johannes;Herzum, Ileana;von Mutius, Erika
背景资料：以前的横断面调查表明，母亲在怀孕期间接触动物棚对儿童的特应性致敏产生了保护作用，一直持续到学龄。目的：我们试图评估孕妇暴露于动物棚和其他农场相关的暴露在怀孕期间对脐带血IgE水平的影响在一个前瞻性的birth cohol.Methods：孕妇生活在农村地区，在奥地利，芬兰，法国，德国，瑞士被招募在妊娠晚期。通过访谈获得了关于孕妇在怀孕期间与农场有关的暴露、营养和健康的信息。食物和常见吸入性过敏原的特异性IgE水平进行了评估，在922名儿童的脐带血和外周血样本的mother.Results：不同的致敏模式，在脐带血的农场和非农场儿童观察。在多变量分析消费煮沸，但不是未煮沸，农场牛奶在怀孕期间与特异性IgE的牛奶独立于母亲的IgE呈正相关。相反，母亲暴露于动物棚和脐带血IgE水平对季节性过敏原之间呈负相关（调整后的比值比，0.38; 95%CI，0.21-0.70）。这种关联没有被母亲的IgE水平混淆。母亲接触干草增强了接触动物棚对脐带血中草花粉IgE水平的保护作用。
Background: Previous cross-sectional surveys have suggested that maternal exposure to animal sheds during pregnancy exerted a protective effect on atopic sensitization in children lasting until school age. Objective: We sought to evaluate the effects of maternal exposure to animal sheds and other farm-related exposures during pregnancy on cord blood IgE levels in a prospective birth cohort.Methods: Pregnant women living in rural areas in Austria, Finland, France, Germany, and Switzerland were recruited in the third trimester of pregnancy. Information on maternal farm-related exposures, nutrition, and health during pregnancy was obtained by means of interviews. Specific IgE levels for food and common inhalant allergens were assessed in cord blood of 922 children and peripheral blood samples of their mothers.Results: Different sensitization patterns in cord blood of farm and nonfarm children were observed. In multivariable analysis consumption of boiled, but not unboiled, farm milk during pregnancy was positively associated with specific IgE to cow's milk independently from maternal IgE. In contrast, there was an inverse relationship between maternal exposure to animal sheds and cord blood IgE levels against seasonal allergens (adjusted odds ratio, 0.38; 95% CI, 0.21-0.70). This association was not confounded by maternal IgE levels. Maternal contact with hay enhanced the protective effect of exposure to animal sheds on IgE levels to grass pollen in cord blood.