The brain decade in debate: I. Neurobiology of learning and memory
The brain decade in debate: I. Neurobiology of learning and memory
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DOI：
10.1590/s0100-879x2000000900002
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发表时间：
2000-09-01
影响因子：
2.3
通讯作者：
Da Cunha, C
中科院分区：
文献类型：
--
作者：
Baddeley, A;Bueno, O;Da Cunha, C
本文是一个电子研讨会的转录，在研讨会上，一些活跃的研究人员应巴西神经科学和行为学会(SBNeC)的邀请，讨论了过去十年在学习和记忆的神经生物学方面的进展。在不同类型的记忆(如短期记忆和长期记忆、陈述性记忆和程序性记忆)的存储过程中，大脑的不同部分被招募的方式，甚至这些划分的性质都被讨论过。有人指出，大脑并不真正存储记忆，但存储了后来用于创造记忆的信息痕迹，并不总是表达过去经历的现实的完全真实的画面。为了执行这一过程，大脑的不同部分充当神经网络的重要节点，对将用于创建记忆的信息进行编码、存储和检索。在激活短期工作记忆(例如，前额叶皮质)、或存储作为长期显性记忆检索的信息(例如，海马体和相关皮质区域)或调制与情绪事件相关的记忆存储(例如，杏仁核)期间，一些大脑区域明显活跃。这并不意味着有一个单独的神经结构完全支持每种记忆的存储，而是意味着这些记忆关键地依赖于这些神经结构的功能。目前的观点是，谈论基于海马体或杏仁核的记忆是没有意义的，因为这意味着存在一一对应关系。目前需要解决的问题是系统如何在内存中相互作用。还讨论了将关键作用归因于突触标记和蛋白激酶A激活等细胞过程以在细胞水平上解释记忆存储过程的相关性。
This article is a transcription of an electronic symposium in which some active researchers were invited by the Brazilian Society for Neuroscience and Behavior (SBNeC) to discuss the last decade's advances in neurobiology of learning and memory. The way different parts of the brain are recruited during the storage of different kinds of memory (e.g., short-term vs long-term memory, declarative vs procedural memory) and even the property of these divisions were discussed. It was pointed out that the brain does not really store memories, bur stores traces of information that are later used to create memories, not always expressing a completely veridical picture of the past experienced reality. To perform this process different parts of the brain act as important nodes of the neural network that encode, store and retrieve the information that will be used to create memories. Some of the brain regions are recognizably active during the activation of short-term working memory (e.g., prefrontal cortex), or the storage of information retrieved as long-term explicit memories (e.g., hippocampus and related cortical areas) or the modulation of the storage of memories related to emotional events (e.g., amygdala). This does not mean that there is a separate neural structure completely supporting the storage of each kind of memory but means that these memories critically depend on the functioning of these neural structures. The current view is that there is no sense in talking about hippocampus-based or amygdala-based memory since this implies that there is a one-to-one correspondence. The present question to be solved is how systems interact in memory. The pertinence of attributing a critical role to cellular processes like synaptic tagging and protein kinase A activation to explain the memory storage processes at the cellular level was also discussed.