High frequency ultrasound backscatter imaging
High frequency ultrasound backscatter imaging
复制标题
高频超声反向散射成像
DOI：
--
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
A. Rauth
中科院分区：
文献类型：
--
作者：
F. Foster;C. Pavlin;G. Lockwood;L. K. Ryan;K. Harasiewicz;L. Bérubé;A. Rauth
超声背散射显微镜（UBM）的发展与最初的临床和生物学应用一起描述。UBM本质上是为3-10 MHz频率范围内的临床成像而开发的强大B模式反向散射方法的扩展。在40-100-MHz范围内的新的高灵敏度换能器的发展，现在允许可视化的组织结构，分辨率接近20 μ m，最大穿透约4 mm。这些新的聚合物和陶瓷器件的性能特点和权衡进行审查，并描述了高频成像系统的实施。UBM最初的临床应用包括眼科、皮肤和血管内成像。在这些领域的图像和进展的例子。UBM的生物学应用通过对肿瘤球体的药物摄取研究来说明。证明了靶向含氧和缺氧细胞群体的药物导致的反向散射水平的显著增加。<<ETX>>
The development of ultrasound backscatter microscopy (UBM) is described together with initial clinical and biological applications. UBM is essentially an extension of the powerful B-mode backscatter methods developed for clinical imaging in the 3-10-MHz frequency range. The development of new high sensitivity transducers in the 40-100-MHz range now permits visualization of tissue structures with resolution approaching 20 mu m and a maximum penetration of approximately 4 mm. The performance characteristics and tradeoffs of these new polymer and ceramic devices are reviewed, and the implementation of high-frequency imaging systems is described. Initial clinical applications of UBM include ophthalmic, skin, and intravascular imaging. Examples of images and progress in these areas is presented. The biological application of UBM is illustrated by studies of drug uptake in living tumor spheroids. Significant increases in backscatter levels resulting from drugs targeting oxic and hypoxic cell populations are demonstrated.<<ETX>>
影响因子：
29.4
作者：
F. E. Silverstein;Roy W. Martin;M. Kimmey;G. Jiranek;D. W. Franklin;Andrew Proctor
通讯作者：
F. E. Silverstein;Roy W. Martin;M. Kimmey;G. Jiranek;D. W. Franklin;Andrew Proctor