Immune system of the spontaneously hypertensive rat: II. Morphology and function.
Immune system of the spontaneously hypertensive rat: II. Morphology and function.
复制标题
自发性高血压大鼠的免疫系统：II．
DOI：
10.1002/ar.1092370211
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Gattone2nd,VH
中科院分区：
文献类型：
--
作者：
Purcell,ES;Wood,GW;Gattone2nd,VH
The spontaneously hypertensive rat (SHR) is a stress‐sensitive animal which exhibits moderate immune dysfunction that has been implicated in the onset of hypertension. In this study, we examined the morphology of SHR thymus and spleen and further characterized the immune deficiency using Wistar‐Kyoto (WKY) and Fisher 344 (F‐344) rats for comparison. The adult SHR thymus does not display the increase in medullary volume typically noted with aging and the volume density of the marginal zone is decreased in the spleen. In vivo tritiated‐thymidine incorporation is also decreased in the spleen of unstimulated SHR. In mixed lymphocyte reactions (MLR), the proliferative response of SHR splenocytes is significantly decreased relative to controls, WKY and F‐344. Addition of interleukin‐1 (IL‐1), interleukin‐2 (IL‐2), or indomethacin to the MLR cultures does not increase proliferation. The proliferative response to T cell receptor monoclonal antibody (mAb‐TCR) or interleukin‐2 (IL‐2) are similarly impaired in the SHR. The depressed proliferative T cell response is reversed by prolactin. It is suggested that the SHR is a valuable model for the study of immune deficiency. © 1993 Wiley‐Liss Inc.
