Role of surgery and transplantation in the treatment of hepatic metastases from neuroendocrine tumor
Role of surgery and transplantation in the treatment of hepatic metastases from neuroendocrine tumor
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DOI：
10.3748/wjg.v20.i39.14348
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发表时间：
2014-10-21
影响因子：
4.3
通讯作者：
Gedaly, Roberto
中科院分区：
文献类型：
--
作者：
Alagusundaramoorthy, Sayee Sundar;Gedaly, Roberto
Neuroendocrine tumors (NET) are a heterogeneous group of cancers, with indolent behavior. The most common primary origin is the gastro-intestinal tract but can also appear in the lungs, kidneys, adrenals, ovaries and other organs. In general, NET is usually discovered in the metastatic phase (40%-80%). The liver is the most common organ involved when metastases occur (40%-93%), followed by bone (12%-20%) and lung (8%-10%). A number of different therapeutic options are available for the treatment of hepatic metastases including surgical resection, transplantation, ablation, trans-arterial chemoembolization, chemotherapy and somatostatin analogues. Recently, molecular targeted therapies have been used, usually in combination with other treatment options, to improve outcomes in patients with metastases. This article emphasizes on the role of surgery in the treatment of liver metastases from NET. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
